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Triple-negative breast cancer (TNBC) diagnosis and treatment: 7 things you should know

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Microbiota in cancer: current understandings and future perspectives

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Male Breast Cancer: What patients should know about

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A Patient’s Guide to Breast Cancer

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What is bilateral breast cancer?

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Post-Prostatectomy Radiation Therapy: Patient Selection, Timing, Imaging, and Therapy Intensification

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A note from history: Landmarks in history of cancer, part 5

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Switching Immune Cells From “Protect” to “Attack” Mode To Treat Prostate Cancer - Technology Networks

- July 03, 2020

Drugs that can ‘reprogramme’ immune cells from protecting cancer to attacking it could be an effective new treatment for some men with advanced prostate cancer, a new study shows. Researchers found that immune cells called macrophages, already drawn into prostate cancer tumours to help promote growth, can be targeted and rewired to attack the disease. In studies of cancer cells and mice with prostate cancer a so-called CXCR2 inhibitor, which blocks a protein receptor on macrophages, inhibited tumour growth by switching them from helping the tumour to triggering anti-tumour immune responses instead. The drug, called AZD5069, is now being studied in a clinical trial led by researchers at The Institute of Cancer Research and our partner hospital The Royal Marsden NHS Foundation Trust, to test its effectiveness in men with advanced prostate cancer. The new research, published in the journal published in the journal Cell Reports , was carried out by a Eur...

Bayer, Orion prep challenge in prostate cancer market - PMLiVE

- February 18, 2019

Bayer and Orion have put some meat on the bones of their phase 3 trial of darolutamide in non-metastatic castration-resistant prostate cancer (CRPC), as they prepare to take on rival therapies from Johnson & Johnson and Pfizer/Astellas. The two partners released top-line results from the ARAMIS trial of darolutamide last year, but have now presented the data in full at the ASCO Genitourinary (GU) symposium and published the study in the New England Journal of Medicine . The verdict of the 1,509-patient trial is that darolutamide added to androgen deprivation therapy (ADT) achieved a 59% reduction in the risk of metastasis or death versus ADT plus placebo, with a median metastasis-free survival of 40.4 months compared to 18.4 months, respectively. There was also a trend towards an increase in overall survival of 29% versus placebo, and patients will be monitored in the coming months to see if this develops into a statistically significant improvement. Bayer and Orion say they...

Genotype linked to shorter survival in metastatic prostate cancer - Urology Times

- March 02, 2020

Inheriting the adrenal-permissive HSD3B1(1245C) genotype is associated with worse outcomes in low-volume metastatic prostate cancer and might someday help identify patients who could benefit from escalated therapy, according to a recent study. In essence, some patients are genetically predisposed to having their prostate cancers make their own potent androgens, such as testosterone or dihydrotestosterone (DHT), from non-testicular sources, according to study author Nima Sharifi, MD, of Cleveland Clinic Genitourinary Malignancies Research Center, Cleveland. “This comes from germline inheritance of an effectively ‘fast’ enzyme by the gene HSD3B1 that allows for prostate cancer to make these androgens. What this means clinically is that men with low-volume metastatic prostate cancer who inherit this fast form of HSD3B1 treated with medical or surgical castration progress more quickly and have shorter survival compared with men who do not inherit this fast enzyme,” Dr. Sharifi said. Re...

Minimally invasive treatment option for enlarged prostate - PAHomePage.com

- February 28, 2019

Predictive Factors and Oncologic Outcome of Downgrade to Pathologic Gleason Score 6⁻7 after Radical Prostatectomy in Patients with Biopsy Gleason Score 8⁻10. - UroToday

- April 07, 2019

Gleason score (GS) 8⁻10 is associated with adverse outcomes in prostate cancer (PCa). However, biopsy GS (bGS) may be upgraded or downgraded post-radical prostatectomy (RP). We aimed to investigate predictive factors and oncologic outcomes of downgrade to pathologic GS (pGS) 6⁻7 after RP in PCa patients with bGSs 8⁻10. We retrospectively reviewed clinical data of patients with bGS ≥ 8 undergoing RP. pGS downgrade was defined as a pGS ≤ 7 from bGS ≥ 8 post-RP. Univariate and multivariate cox regression analysis, logistic regression analysis, and Kaplan⁻Meier curves were used to analyze pGS downgrade and biochemical recurrence (BCR). Of 860 patients, 623 and 237 had bGS 8 and bGS ≥ 9, respectively. Post-RP, 332 patients were downgraded to pGS ≤ 7; of these, 284 and 48 had bGS 8 and bGS ≥ 9, respectively. Prostate-specific antigen (PSA) levels; clinical stage; and adverse pathologic features such as extracapsular extension, seminal vesicle invasion and positive surgical margin were signif...

Tumor biomarkers for diagnosis, prognosis and targeted therapy | Signal Transduction and Targeted Therapy

- December 24, 2024

warning signs of colon cancer :: Article Creator I'm A 34-year-old With Colon Cancer And I Don't Know How Long I Have Left - I Kick Myself For Ignoring Two Key Warning Signs By JONATHAN NEAL FOR MAILONLINE Published: 06:42 EST, 9 December 2024Updated: 16:55 EST, 11 December 2024 A 34-year-old man diagnosed with incurable colon cancer has revealed the key symptoms he dismissed — in a bid to help others avoid the same fate. Joe Faratzis first began suffering problems in 2019, including 'a dull, mild ache' in the lower right of his abdomen from time to time that 'was easy to ignore and forget about'. He visited his doctor who asked about his bowel habits and referred him for scans but, heartbreakingly, Mr Faratzis didn't go through with the tests, admitting: 'I assumed it was unnecessary.' Six months later he began noticing blood on the toilet paper when he went to the bathroom, but again claims he 'wasn...

After Beating Cancer Twice, Larry King, 87, Has Died– Legendary Talk Show Host Had Incredible Staying Power - SurvivorNet

- August 18, 2021

Larry King, Hospitalized With COVID-19, Is a Warrior Larry King Live talk show host Larry King, 87, is currently in the hospital fighting COVID-19; he reportedly left the ICU on Sunday. King survived lung cancer in 2017 and prostate cancer in 1999; he has also suffered a stroke and heart disease in the past. For people battling cancer during the COVID-19 pandemic, it's especially important to exercise safety precautions, due to some cancer treatments leading to an immunocompromised state. Legendary TV host and broadcast journalist, Larry King, 87, has spoken of his "indomitable spirit" which allowed him to overcome multiple health issues, including lung cancer in 2017; now, King has passed away from cancer after a battle with COVID. He had previously been treated at Cedars Sinai Medical Center in Los Angeles. And due to safety protocols, it's being reported by CNN that his three sons are not able to visit him in the hospital. Related: A Message on World Lung Cancer D...

Iowa News Anchor Showered With Support After Revealing Breast ...

- June 27, 2023

prostate screening :: Article Creator Prostate Cancer Screening And The Golden Rule Of Humanity Takeshi Takahashi, public health physician, former urological surgeon Health and Welfare Bureau, Kitakyushu city office, Jyonai 1-1, Kitakyushu 803-8501, Japan jazzy{at}kuhp.Kyoto-u.Ac.Jp The discussion around prostate cancer screening continues.1 I worked as a urologist for 30 years. When I was young, I hoped only to become an independent urologist and to gain as much surgical experience as possible. But as I approached the target age for prostate specific antigen (PSA) screening, and having heard the opinions of public health experts,23 I could no longer recommend PSA … Senior Living: How To Treat, Prevent Prostate Issues, Including Cancer By Dr. Jennifer Liu, Guest columnist Prostate health is an important issue in aging men. Major health complications can arise from prostate issues, including prostate cancer, decreased quality...

Prostate cancer: Investigating the impact of diet - Medical News Today

- October 23, 2019

A recent review searches for links between dietary choices and prostate cancer. The authors conclude that there may be an association between plant based diets and a decreased risk of prostate cancer, as well as a link between dairy intake and increased risk. Share on Pinterest The relationship between diet and disease will not give up its secrets easily. According to the National Cancer Institute, there will be an estimated 174,650 new cases of prostate cancer in the United States this year. In the U.S., about 11.6% of men will receive a diagnosis of prostate cancer at some point during their lifetime. As with other types of cancer , scientists are still uncovering the full range of risk factors for prostate cancer. Some scientists have turned to nutrition , but — for various reasons — measuring the effect of the diet on disease is notoriously difficult. As one example, food intake can fluctuate wildly from day to day, month to month, and year to year. Also, certain dietary ...

Tips to be fit: Should you get prostate cancer screening? - The Philadelphia Tribune

- February 24, 2020

Recent news article have suggested that healthy men don’t need to have routine prostate screenings. At first you might say, “Well I’m healthy. Maybe I’ll skip it this time.” Should you? A few years ago the United States Preventive Services Task Force said in a report that routine “prostate-specific antigen” (PSA) screenings does not save lives. Their conclusion was based on five major clinical studies. The two largest studies conducted in the U.S. and Europe found that the death rates of men who got prostate screenings were virtually the same as those who didn’t. Is this reason enough not to have a routine prostate screenings? What most people and even some doctors don’t understand is that a PSA screening is not a specific test for cancer. It’s a test that can detect abnormalities. It doesn’t identify a particular problem. One doctor put it this way “A PSA screening is like an engine warning light. When it flashes, you can’t tell if a particular spark plug is bad. It tells you on...

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