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Prostate Cancer | Annals of Internal Medicine

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- June 07, 2026

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Tumor biomarkers for diagnosis, prognosis and targeted therapy | Signal Transduction and Targeted Therapy

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- June 07, 2026

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A Patient’s Guide to Breast Cancer

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- June 06, 2026

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Male Breast Cancer: Symptoms, Causes and Treatment

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- June 06, 2026

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Treatment Path for HR+/HER2- mBC

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- June 06, 2026

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Can Your Cancer Treatment Be Hazardous to Others?

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- June 05, 2026

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Turmeric and Prostate Cancer: Does It Work?

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- June 05, 2026

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Lung Cancer: Diagnosis, Treatment Principles, and Screening

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Expert Discusses Data From First Positive Trial for PARP Inhibitor in Prostate Cancer - Targeted Oncology

- November 05, 2019

Alan Bryce, MD PARP inhibition with olaparib (Lynparza) improved radiographic progression-free survival (rPFS) in heavily pretreated patients with metastatic castration-resistant prostate cancer (mCRPC) who had alterations in homologous recombination repair (HRR) genes, according to findings from the phase III PROfound trial presented at the 2019 ESMO Congress. This was the first positive randomized phase III trial reported evaluating a PARP inhibitor in men with mCRPC. The PROfound trial enrolled patients to 2 cohorts. In cohort A, 245 patients with BRCA1/2 or ATM alterations, markers of HRR, were randomized 2:1 to receive either olaparib (n = 162) or physician’s choice of abiraterone acetate (Zytiga) with prednisone or enzalutamide (Xtandi) (n = 83). In cohort B, 142 patients with alterations in the BARD1, BRIP1, CDK12, CHEK1/2, FANCL, PALB2, PPP2R2A, RAD51B/C/D , or RAD54L , all of which are associated with HRR indirectly, were also randomized 2:...

Cold and hot tumors: from molecular mechanisms to targeted therapy

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Prostate Cancer Upgrading on AS Linked to Perineural Invasion - Renal and Urology News

- July 25, 2022

Perineural invasion detected on biopsy in patients on active surveillance for low-risk prostate cancer is strongly associated with upgrading, investigators reported at the American Urological Association's 2022 annual meeting in New Orleans, Louisiana. Among 1969 patients in the 1995-2021 Johns Hopkins active surveillance (AS) registry, 1282 men were diagnosed with very low-risk and 687 men with low-risk disease. The median PSA level was 4.9 ng/mL. Over a median follow-up of 36 months on AS, 198 men (10.0%) displayed perineural invasion on at least 1 biopsy, including at diagnosis. "Perineural invasion — the presence of cancerous cells tracking along or around a nerve within the perineural space — is a well-established mechanism by which prostate cancer cells spread outside of the capsule," Claire M. de la Calle, MD, of Johns Hopkins University, Baltimore, Maryland explained in an interview. "It can be found in low-grade tumors and tumors that ...

Cancer Patients Reveal The Symptom That Made Them Think Something Might Be Wrong

- April 29, 2026

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Penis cancer: How GPs mistake it for a sexual disease... but it can rob a man of his genitals - Daily Mail

- July 24, 2022

How GPs mistake penis cancer for a sexual disease... and it can rob a man of his genitals Hundreds of British men are forced to undergo life-altering surgery every year because doctors are missing the warning signs of penis cancer, experts say Disease, which affects around 700 men every year, can be cured if spotted early, with little impact on sex life Studies show half of all penis cancers are diagnosed at a late stage – when it's impossible to save the organ; a fifth of patients die from the disease By Ethan Ennals For The Mail On Sunday Published: 23:07 BST, 16 July 2022 | Updated: 23:07 BST, 16 July 2022 Hundreds of British men are forced to undergo life-altering surgery every year because doctors are missing the warning signs of penis cancer, experts say. The disease, which affects around 700 men every year, can be cured if spotted early, with little impact on sex life. But studies show ...

Sleep disorders in cancer: interactions and intrinsic links

- April 20, 2026

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Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition

- April 27, 2026

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How to detect colon cancer without a colonoscopy

- June 28, 2024

ketogenic diet and cancer :: Article Creator Could Diet Help Fight Brain Cancer? A British man who rejected the standard of care to treat his brain cancer has lived with the typically fatal glioblastoma tumor growing very slowly after adopting a ketogenic diet, providing a case study that researchers say reflects the benefits of using the body's own metabolism to fight this particularly aggressive cancer instead of chemo and radiation therapy. Published recently in the journal Frontiers in Nutrition, the report is the first evaluation of the use of ketogenic metabolic therapy (KMT) without chemo or radiation interventions, on a patient diagnosed with IDH1-mutant glioblastoma (GBM), said Boston College Professor of Biology Thomas Seyfried, a co-author of the report. Ketogenic therapy is a non-toxic nutritional approach, viewed as complementary or alternative, that uses a low-carbohydrate, high-fat diet to manage a range of cancers, including glio...

News 8 On Call: Men’s Health Awareness Month – Prostate Cancer - WTNH.com

- November 15, 2019

NEW HAVEN, Conn. (WTNH) – News 8 is on call for you. November is Men’s Health Awareness Month. Experts say men worry a lot about prostate cancer . Over two million men in the United States live with prostate cancer, and about 180,000 are diagnosed yearly. “A big change happened when we started screening about 20 years, 25 years ago. Most prostate cancers we find today are very small, they’re contained and highly curable,” says Dr. Michael Leapman. Dr. Leapman specializes in prostate cancer at Yale Cancer Center. Some common questions from patients: Is it genetic? He says, “It’s a good thing to pay attention to your family history. We hear a lot about the BRCA mutations for breast cancer and ovarian cancer in women but men who have a BRCA mutation are at greater risk for developing prostate cancer.” Is it something I did? “The answer is no,” says Dr. Leapman, “It’s not something that anyone did. It is completely out of someone’s control. There’s a lot of interest in diet, lifes...

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