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Can Your Cancer Treatment Be Hazardous to Others?

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- June 05, 2026

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Turmeric and Prostate Cancer: Does It Work?

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- June 05, 2026

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Smart nanoparticles for cancer therapy

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- June 05, 2026

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Bladder Cancer Treatment & Pharmacologic Management

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- June 01, 2026

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Can Your Cancer Treatment Be Hazardous to Others?

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- June 01, 2026

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Smart nanoparticles for cancer therapy

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- June 01, 2026

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Bladder Cancer Treatment & Pharmacologic Management

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Lung Cancer: Diagnosis, Treatment Principles, and Screening

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Expert Discusses Data From First Positive Trial for PARP Inhibitor in Prostate Cancer - Targeted Oncology

- November 05, 2019

Alan Bryce, MD PARP inhibition with olaparib (Lynparza) improved radiographic progression-free survival (rPFS) in heavily pretreated patients with metastatic castration-resistant prostate cancer (mCRPC) who had alterations in homologous recombination repair (HRR) genes, according to findings from the phase III PROfound trial presented at the 2019 ESMO Congress. This was the first positive randomized phase III trial reported evaluating a PARP inhibitor in men with mCRPC. The PROfound trial enrolled patients to 2 cohorts. In cohort A, 245 patients with BRCA1/2 or ATM alterations, markers of HRR, were randomized 2:1 to receive either olaparib (n = 162) or physician’s choice of abiraterone acetate (Zytiga) with prednisone or enzalutamide (Xtandi) (n = 83). In cohort B, 142 patients with alterations in the BARD1, BRIP1, CDK12, CHEK1/2, FANCL, PALB2, PPP2R2A, RAD51B/C/D , or RAD54L , all of which are associated with HRR indirectly, were also randomized 2:...

Cancer treatment and survivorship statistics, 2025

- April 26, 2026

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Cancer Patients Reveal The Symptom That Made Them Think Something Might Be Wrong

- April 25, 2026

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CDK12 is a potential biomarker for diagnosis, prognosis and immunomodulation in pan-cancer

- October 11, 2024

germ cell tumor diagnosis :: Article Creator Managing Germline Mutations In Hereditary Breast Cancer Risk Hereditary breast cancer, which accounts for 5% to 10% of all cases of breast cancer,1 is the direct result of a genetic predisposition to a higher lifetime risk of breast cancer due to its inherent inherited nature compared with the general population, and it can significantly affect family health outcomes. This risk is inherited at conception and stems from germline mutations that exist in the germ cells that develop into reproductive cells and become eggs in female individuals and sperm in male individuals and are passed from parent to child.2 Each germ cell contains half of the chromosomes necessary for development, and mutations from them exist in every cell of an individual.3 Kate Baker, MD, MMHCImage Credit: © Tennessee Oncology "Nonhereditary breast cancer, also known as sporadic breast cancer, occurs when gene mut...

Cold and hot tumors: from molecular mechanisms to targeted therapy

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Deep Learning With Radiomics for Disease Diagnosis and Treatment: Challenges and Potential

- April 26, 2026

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Prostate Cancer Upgrading on AS Linked to Perineural Invasion - Renal and Urology News

- July 25, 2022

Perineural invasion detected on biopsy in patients on active surveillance for low-risk prostate cancer is strongly associated with upgrading, investigators reported at the American Urological Association's 2022 annual meeting in New Orleans, Louisiana. Among 1969 patients in the 1995-2021 Johns Hopkins active surveillance (AS) registry, 1282 men were diagnosed with very low-risk and 687 men with low-risk disease. The median PSA level was 4.9 ng/mL. Over a median follow-up of 36 months on AS, 198 men (10.0%) displayed perineural invasion on at least 1 biopsy, including at diagnosis. "Perineural invasion — the presence of cancerous cells tracking along or around a nerve within the perineural space — is a well-established mechanism by which prostate cancer cells spread outside of the capsule," Claire M. de la Calle, MD, of Johns Hopkins University, Baltimore, Maryland explained in an interview. "It can be found in low-grade tumors and tumors that ...

Cancer Patients Reveal The Symptom That Made Them Think Something Might Be Wrong

- April 29, 2026

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Penis cancer: How GPs mistake it for a sexual disease... but it can rob a man of his genitals - Daily Mail

- July 24, 2022

How GPs mistake penis cancer for a sexual disease... and it can rob a man of his genitals Hundreds of British men are forced to undergo life-altering surgery every year because doctors are missing the warning signs of penis cancer, experts say Disease, which affects around 700 men every year, can be cured if spotted early, with little impact on sex life Studies show half of all penis cancers are diagnosed at a late stage – when it's impossible to save the organ; a fifth of patients die from the disease By Ethan Ennals For The Mail On Sunday Published: 23:07 BST, 16 July 2022 | Updated: 23:07 BST, 16 July 2022 Hundreds of British men are forced to undergo life-altering surgery every year because doctors are missing the warning signs of penis cancer, experts say. The disease, which affects around 700 men every year, can be cured if spotted early, with little impact on sex life. But studies show ...

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