Prostate Cancer

Serial stereotactic body radiation therapy (SBRT) directed by positron emission tomography (PET) using novel radiotracers may offer clinical benefits in patients with oligometastatic prostate cancer, according to a recent retrospective study. The study's findings suggest that a second course of SBRT for men with recurrent oligometastatic prostate cancer following an initial course of SBRT is an important therapeutic strategy to consider, Daniel H. Kwon, MD, of the University of California, San Francisco, and colleagues reported in Urologic Oncology . The study included 25 men with 1-5 prostate cancer metastases detected on PSMA (prostate-specific membrane antigen) or fluciclovine PET and who underwent 2 consecutive courses of SBRT. At the time of the second SBRT course, PSMA and fluciclovine PET detected oligorecurrent disease in 17 (68%) and 8 (32%) patients, respectively. Of the 25 patients, 15 (60%) had castration-sensitive disease and 10 (40%) had castrat...

Abstract Radiation therapy (RT) can enhance the abscopal effect of immune checkpoint blockade. This phase I/II study investigated the efficacy and safety of nivolumab plus RT in HER2-negative metastatic breast cancer requiring palliative RT for bone metastases. Cohort A included luminal-like disease, and cohort B included both luminal-like and triple-negative disease refractory to standard systemic therapy. Patients received 8 Gy single fraction RT for bone metastasis on day 0. Nivolumab was administered on day 1 for each 14-day cycle. In cohort A, endocrine therapy was administered. The primary endpoint was the objective response rate (ORR) of the unirradiated lesions. Cohorts A and B consisted of 18 and 10 patients, respectively. The ORR was 11% (90% CI 4–29%) in cohort A and 0% in cohort B. Disease control rates were 39% (90% CI 23–58%) and 0%. Median progression-free survival was 4.1 months (95% CI 2.1–6.1 months) and 2.0 months (95% CI 1.2–3.7...

DUBLIN--( BUSINESS WIRE )--The "Global Prostate Cancer Minimally Invasive Surgery Market (2022-2027) by Product Type, Application, and Geography, Competitive Analysis and the Impact of Covid-19 with Ansoff Analysis" report has been added to ResearchAndMarkets.com's offering. The Global Prostate Cancer Minimally Invasive Surgery Market is estimated to be USD 19.25 Bn in 2022 and is expected to reach USD 30.03 Bn by 2027, growing at a CAGR of 9.3%. Market dynamics are forces that impact the prices and behaviors of the Global Prostate Cancer Minimally Invasive Surgery Market stakeholders. These forces create pricing signals which result from the changes in the supply and demand curves for a given product or service. Forces of Market Dynamics may be related to macro-economic and micro-economic factors. There are dynamic market forces other than price, demand, and supply. Human emotions can also drive decisions, influence the market, and create price signals. As ...

Although melanoma is the most serious skin cancer, most patients do have high chances of survival. New research has now identified a subset of patients with early disease who have a very low risk of dying from the disease. In a cohort of almost 11,600 patients, the overall 7-year rate of death from melanoma was 2.5%, but the risk in a subset of 25% of patients was below 1%. Conversely, the study authors were also able to identify a small subset of high‐risk patients with a greater than 20% risk for death. Though more data are needed and the findings verified in other studies, the use of a different term such as "melanocytic neoplasm of low malignant potential" may be more appropriate and may help to begin to address the problem of overdiagnosis, they note. "While the topic of very low risk melanomas has been presented at national and international meetings, there have been no formal discussions to define the cla...

WORCESTER, Mass. - Saint Vincent Hospital is now the first central Massachusetts hospital to offer aquablation therapy, and one of five in the state. The therapy is a minimally invasive robotic treatment designed to help treat benign prostatic hyperplasia, a non-cancerous enlarged prostate. What You Need To Know Aquablation therapy is an advanced, minimally invasive treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) The therapy is performed by the AquaBeam Robotic System, which is the first FDA-cleared, surgical robot utilizing automated tissue resection or the treatment of LUTS due to BPH Dr. Bhalchandra Parulkar said by the age of 60, one out of two people have an enlarged prostate. By the age of 80, almost 100% have an enlarged prostate Saint Vincent Chief of Urology Dr. Bhalchandra Parulkar said by the age of 60, one out of two people have an enlarged prostate and by the age ...

[unable to retrieve full-text content] Advancements in Radiation Therapy to treat Prostate Cancer    APN News

Endometrial carcinoma is the most common gynecological neoplasm. It is estimated that 3.6% of patients with endometrial carcinoma develop lung metastases [1]. Out of all gynecologic malignancies, endometrial carcinoma has the highest frequency of pulmonary metastases. Metastatic endometrial carcinoma to the lungs most commonly presents with pulmonary nodules [2]. A malignant effusion is less commonly found in metastatic endometrial carcinoma of the lungs [1,2]. Uterine cancer most frequently spreads to para-aortic and pelvic lymph nodes. The spread to the pleura or lung is hematogenous. The other less common sites of metastasis from endometrial cancer are paranasal sinuses, heart, brain, and scalp [3]. A 76-year-old female patient presented to the hospital for evaluation of shortness of breath and was found to have bilateral pleural effusions seen in a CT scan of the chest. Her comorbidities included asthma, hyperlipidemia, neuropathy, and stage IA endometrial papillary serous ad...

IN the run-up to New Year's Eve, some supermarkets and pharmacies still have reduced hours, so act now to make sure your medicine cabinet is in good shape. It's reassuring to have all the usual suspects stashed in case anyone comes down with a cold, flu, Covid or a particularly bad hangover. 1 Dr Zoe Williams answers some common questions sent in by readers And it's a good idea to have on hand pain-relief tablets (paracetamol, ibuprofen), antihistamines for allergies, indigestion tablets and rehydration sachets for replacing fluid and minerals lost via any sickness or diarrhoea. Check you're fully stocked with plasters, sterile gauze, bandages, antiseptic and medical tape. If you don't have such a medical kit, get one – you never know when you might need it – and store it out of reach of children. Here are some of the questions readers asked me this week . . .  Q) I AM worried that I might have ovarian cancer as my stomach is always bloated. A) Ther...

Companies Moderna Inc Follow Merck & Co Inc Follow BioNTech SE Follow Roche Holding AG Follow Gritstone bio Inc Follow CHICAGO, Dec 13 (Reuters) - An experimental cancer vaccine from Moderna Inc (MRNA.O) based on the messenger RNA (MRNA) technology used in successful COVID-19 vaccines has been shown to work against melanoma, sending Moderna shares more than 20% higher and driving up of other biotechs working on similar treatments. A combination of Moderna's personalized cancer vaccine and Merck & Co's (MRK.N) blockbuster immunotherapy Keytruda cut the risk of recurrence or death of the most deadly skin cancer by 44% compared with Keytruda alone in a mid-stage trial, the companies said on Tuesday. The result was considered a "statistically significant and clinically meaningful improvement," the companies said. Moderna shares were up nearly 23% at $202.80 on Tuesday, while Merck's shares rose 1%. Shares of BioNTech SE (22UAy.DE), which also has succe...