Prostate Cancer

Common gut bacteria can fuel the growth of prostate cancers and allow them to evade the effects of treatment, a new study finds. Scientists revealed how gut bacteria contribute to the progression of advanced prostate cancers and their resistance to hormone therapy -- by providing an alternative source of growth-promoting androgens, or male hormones. Hormone therapy is the standard of care for advanced prostate cancer and works by lowering levels of androgens. But researchers found that low androgen levels in patients can drive the expansion of gut bacteria, which can become hormone factories to sustain prostate cancer growth. Bacterial 'fingerprints' identified by scientists may help pick out patients at high risk of developing resistance to treatment who could benefit from strategies to manipulate their 'microbiome'. For example, men could undergo a faecal transplant or take a yoghurt drink enriched with favourable bacteria. A team of scientists from The Instit...

Introduction Radical cystectomy (RC) is the standard treatment for certain stages of bladder cancer. For the high-risk group of patients with non-muscle invasive bladder cancer (NMIBC), both the European Association of Urology (EAU) and American Urological Association (AUA) guidelines recommend treatment with bacille Calmette–Guérin (BCG). 1,2 However, even in these patients RC is carried out. Yafi et al, for example, reported on 2287 RCs performed in Canada between 1998 and 2008, and the distribution of clinical staging was NMIBC in 26.3% (cTis in 4.8%, cTa in 2.9%, and cT1 in 18.6%). 3 The reasons for performing an RC include unresectable non-invasive tumors and BCG unresponsiveness. Indeed, the latter situation is one of the reasons for recommending RC. The AUA guideline recommends RC in fit patients with high-grade T1 tumors after BCG induction, or T1 tumors with carcinoma in situ (CIS), lymphovascular invasion (LVI), or variant histologies (VH). 2 This translates into a mod...

[unable to retrieve full-text content] Flu shots, lab tests available Nov. 6 | Hillsboro Star-Journal | Oct. 28, 2021    Hillsboro Star-Journal

Acral lentiginous melanoma (ALM) is a form of skin cancer that appears on the palms of the hands, the soles of the feet, or under the nails. ALM accounts for 2–3% of all melanomas. It is not common in the general population, but it is the most common form of skin cancer affecting African Americans. In this article, we look at the symptoms of ALM, how doctors diagnose and stage it, and the treatment options. Most melanomas result from exposure to ultraviolet (UV) radiation from the sun. They occur most often in people with light skin, which is more prone to damage from UV radiation. ALM, however, does not appear to stem from sun exposure. It can affect people with any skin color, but it is the leading cause of melanoma in people with darker skin. ALM is a type of melanoma that develops on the palms, soles, and the skin under the nails. ALM sometimes develops from an existing mole, but it can also occur for no apparent reason on healthy skin. Find out more about how skin cancer affects ...

NEW YORK – Researchers from the Ontario Institute for Cancer Research have developed an algorithm that can better classify cells from the tumor microenvironment and provide tissue of origin based on single-cell transcriptomics data. In a talk at the annual meeting of the American Society of Human Genetics, held virtually last week, Ido Nofech-Mozes, a graduate student at the University of Toronto, described how his team developed a tool for the automated annotation of cancerous, immune, and stromal cells in single-cell RNA-seq cancer research. Manual annotation of these cells is difficult because a "large degree of interpatient heterogeneity in cancer cells makes it hard to find consistent markers that can be used across cancer samples," he said. "Cancer cells tend to cluster by patient and not by cell type, even," he said. To build the algorithm, Nofech-Mozes and his colleagues used reference data from a paper published last year providing single-c...

[unable to retrieve full-text content] Quit Smoking Before 45 & Wipe Out 87% of Lung Cancer Risk | Health News | US News    U.S. News & World Report

Na Kim FFC on 6, 7, 8 Exhibit at the Institute of Contemporary Art ICA presents a new series, Outside In , that will visually transform ICA's 36th Street façade, a space that has a distinct presence, to be experienced both by passersby from the vantage of the street and by visitors within ICA's ramp space gallery. With each iteration, ICA will select from an interdisciplinary range of artists, poets, and designers and invite them to collaborate with Maharam—a forward-thinking textile company based in New York known for their innovative graphic wall installations and commitment to design. Each commission will provide the invited artist with the opportunity to work with Maharam's unique materials and production expertise to create a site-specific artwork that welcomes publics from multiple vantage points and...