Prostate Cancer

It is very important that your doctor check you or your child's progress at regular visits  to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. If you or your child have left upper stomach pain or shoulder pain,  contact your doctor right away . This could be a symptom of a serious side effect with the spleen. Check with your doctor right away at the first sign of any infection, including fever, chills, cough, sore throat, or redness, swelling, or pain around a cut or sore. Check with your doctor right away if you or your child develop a fever, chest pain or tightness, fast breathing, or trouble breathing. These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS). This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you hav...

The European Medicines Agency Committee for Medicinal Products for Human Use has recommended that rucaparib no longer be used as monotherapy for the third-line treatment of patients with platinum-sensitive, relapsed or progressive BRCA-mutated high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer. The European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use (CHMP) has recommended that rucaparib (Rubraca) no longer be used as monotherapy for the third-line treatment of patients with platinum-sensitive, relapsed or progressive BRCA -mutated high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer following at least 2 lines of platinum-based chemotherapy and who cannot tolerate additional platinum-based therapy. 1 The recommendation was made following the final analysis of the phase 3 ARIEL4 study (NCT02855944), in which rucaparib failed to elicit an improvement in median overall survival at 19.4 months, compared with 25...

HOUSTON – (Aug. 22, 2022) – Rice University and Baylor College of Medicine researchers have shown they can eradicate advanced-stage mesothelioma tumors in mice in just a few days with a treatment combining Rice's cytokine "drug factory" implants and a checkpoint inhibitor drug. [embedded content] The researchers administered the drug-producing beads, which are no larger than the head of a pin, next to tumors where they could produce continuous, high doses of interleukin-2 (IL-2), a natural compound that activates white blood cells to fight cancer. From left, Amanda Nash, Dr. Bryan Burt, Omid Veiseh and Samira Aghlara-Fotovat. (Photo by Jeff Fitlow/Rice University) The study, published online today in Clinical Cancer Research, is the latest in a string of successes for the drug-factory technology invented in the lab of Rice bioengineer Omid Veiseh, including Food and Drug Administration (FDA) approval to begin clinical trials of the technology this fal...

Trial in progress poster also to be presented for Phase 1/2 ARROS-1 study of ROS1-selective inhibitor NVL-520 CAMBRIDGE, Mass. , Aug. 5, 2022 /PRNewswire/ -- Nuvalent, Inc. (Nasdaq: NUVL), a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer, today announced new preclinical data supporting the potential best-in-class profile of NVL-655 – an ALK-selective inhibitor, and a "Trial in Progress" poster for the Phase 1/2 ARROS-1 study of NVL-520 – a ROS1-selective inhibitor. NVL-520 and NVL-655 are central nervous system (CNS)-penetrant kinase inhibitors designed to specifically solve for the dual challenges of kinase resistance and selectivity commonly observed with currently available inhibitors. The two posters will be presented at the IASLC 2022 World Conference on Lung Cancer (WCLC) Annual Meeting taking place August 6-9, 2022 in Vienna, Austria . The posters will also be available on ...

A rescue dog's reaction to being put on a diet has left the internet in stitches this week, with even his owner branding him "dramatic." On Monday, Reddit user Kim—name changed for privacy reasons—shared the video of their dog Finny on the popular forum r/WhatsWrongWithMyDog where it has received over 11,000 upvotes and hundreds of comments. Our pets needing to be on a diet is not unusual. In fact, VCA Animal Hospitals says that approximately 25-30 percent of the general canine population is obese, with 40-45 percent of dogs aged 5-11 years weighing higher than recommended. Obesity has been found to shorten a dog's life expectancy and leave them more likely to develop diseases including cancer, arthritis, bladder issues, and being less heat tolerant. Your vet is the best person to advise you on your dog's weight, which is exactly how this Reddit user discovered that their pup needed to be put on a diet. Rescue dog Finny has left viewers in stitches after a video...

Read the Full Video Transcript Alicia Morgans: Hi, I'm so excited to be at ASCO 2022, where I have the opportunity to speak with Brenda Martone, who's a nurse practitioner at Northwestern University. Thank you so much for being here with me today. Brenda Martone: Thanks Alicia. It's really great to see you. Alicia Morgans: It's great to see you too and I'm excited to talk with you about Radium because this is a drug that we actually use together when we practice together. And is one that I think is important from my perspective, at least to keep in our clinical armamentarium as a drug that both improves quality of life and also improves overall survival in patients with metastatic CRPC. One of the things that I think we need to recognize though, is that we do need to identify the right patients and that's true of any therapy that we use. In your practice, how are you thinking about identifying patients for Radium treatment? Brenda Martone:  When ...

Prostate cancer is the most common cancer diagnosis in men worldwide, with a total of approximately 1,280,000 new cases and 359,000 deaths reported in 2018 [1-3]. High-risk prostate cancer patients are treated either with external beam radiotherapy (RT) with long-course androgen deprivation therapy or with radical prostatectomy (optionally associated with pelvic lymphadenectomy) followed by immediate adjuvant radiotherapy (IART) when adverse risk factors are present [4]. Based on existing data, both strategies are equivalent in their rate of tumor control, but each results in different side effects [5]. Surgery often causes urinary incontinence, erectile dysfunction (particularly when no nerve-sparing techniques are used), urethral strictures, and inguinal hernias. In contrast, RT with androgen deprivation therapy often results in increased bowel and bladder irritation and high rates of bone and cardiovascular events [6-8]. Determining a...