Prostate Cancer

Tanya Dorff, MD, medical oncologist, associate clinical professor, Department of Medical Oncology & Therapeutics Research, City of Hope, discusses the investigation of PARP inhibitors in metastatic castration-resistant prostate cancer (mCRPC). New data have presented clinicians with the idea of utilizing PARP inhibitors in combination with androgen receptor (AR) inhibitors in patients with mCRPC, irrespective of homologous recombination repair (HRR) mutation status, Dorff says. Updated data from the phase 3 PROpel trial (NCT03732820) presented at the 2022 ESMO Congress showed that patients treated with olaparib (Lynparza) plus abiraterone acetate (Zytiga) and prednisone or prednisolone experienced a median radiologic progression-free survival (rPFS) of 25.0 months, compared with 16.4 months for those given abiraterone acetate and prednisone or prednisolone alone. Although the phase 3 MAGNITUDE trial (NCT03748641) of niraparib (Zejula) plus abiraterone acetate vs abiraterone ace...

Pain, bloating, and changes in bowel habits could indicate early symptoms of ovarian cancer (Shutterstock) In recent news, a study analysed purchasing information of around 300 women using information from their loyalty cards and were able to spot cases of ovarian cancer just by what products they bought. In the study, researchers found those who had a "noticeable increase" in the purchase of pain and indigestion medication were among those who were later diagnosed with ovarian cancer, compared to women who did not have the disease. These changes in their purchasing habits occurred eight months before a diagnosis, with previous results showing ovarian cancer symptoms appearing roughly four months before diagnosis. It also indicated how many women are treating their initial symptoms at home, often seeing their GP when it could be too late. What is ovarian cancer? Ovarian cancer is the sixth-most common cancer in females in the UK, with around 7,500 new cases every year. The di...

All owners dread the day they'll have to say goodbye to their dogs, and even though it's known that their life span will inevitably be shorter than ours, accepting their loss is still an awful process. The internet was left in tears after a video of a dog, Lexi, who recently passed due to bone cancer, went viral on social media. The clip, shared on TikTok on Wednesday by the pup's owner, under the username Lozzyp_89, shows the dog's owner picking her up from the floor, and giving her one last hug, before crossing the rainbow bridge. The video comes with a caption that reads: "The moment we knew you were ready." The owner also added: "Everybody told me that this moment would come... I just didn't think it would happen 6 weeks after we found out it was bone cancer." Stock image of an owner's hand holding a sick dog's paw. The internet was left in tears by a cancer-stricken dog crossing the rainbow bridge. Getty Images Bone cancer or, ...

From back pain to constipation: Tell-tale symptoms of cervical cancer REVEALED Lower back pain and unusual vaginal bleeding could be signs of cervical cancer  But lesser-known symptoms include bone pain, leg swelling and constipation To mark cervical cancer awareness week, here are the warning signs to look for  By Hannah Mcdonald For Mailonline Published: 09:43 GMT, 24 January 2023 | Updated: 11:37 GMT, 24 January 2023 It's a cruel disease which kills thousands across Britain and the US each year.  Yet awareness of cervical cancer's tell-tale symptoms remains low, charities say. To mark cervical cancer awareness week, MailOnline looked at the well-known, and less-so, symptoms to watch out for. Unusual vaginal bleeding  Lisa Jacques, lead specialist cancer nurse at online cancer resource Perci Health, said unusual vagina...

The American Cancer Society (ACS) has released its annual report on cancer facts and trends. The findings trumpet a victory over cervical cancer — and sound a call-to-arms for fighting prostate cancer. Cancer mortality has fallen 33% since 1991. That's a reduction of around 3.8 million deaths. But perhaps the report's most encouraging finding was a reported 65% drop in cervical cancer rates among 20- to 24-year-old women from 2012-2019. "There's really astounding, important news showing that the efforts that our children went through over the last 20 years or so to go through vaccinations have actually saved lives," said ACS's chief science officer, Dr. William Dahut. Cervical cancer numbers have fallen since the screening boom of the 1970s, but at a shallower rate of around 20%-30% over a decade. This steepening shift could offer new hope for preventing other HPV- and infection-related cancers. "We know of Merkel cell cancers; we have hepatitis and other...

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49. Article  Google Scholar  Hurwitz LM, Agalliu I, Albanes D, Barry KH, Berndt SI, Cai Q, et al. Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research. J Natl Cancer Inst. 2021;113(6):727–34. Article  PubMed  Google Scholar  Prensner JR, Rubin MA, Wei JT, Chinnaiyan AM. Beyond PSA: the next generation of prostate cancer biomarkers. Sci Transl Med. 2012;4(127):127rv123. Article  Google Scholar  Platz EA, De Marzo AM, Giovannucci E. Prostate cancer association studies: pitfalls and solutions to cancer misclassification in the PSA...

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