Identifying the root of prostate cancer treatment resistance using liquid biopsy - Fred Hutch News Service

-

Ha will use the two-year, $200,000 award to shed light on what is known as metastatic castration-resistant prostate cancer, an advanced stage of disease that has become resistant to androgen-deprivation therapy, a type of anti-hormone therapy. This type of cancer is lethal and incurable.

“Abnormal changes can occur in the DNA of tumor cells and give them the ability to resist standard treatments,” Ha said. While monitoring tumor DNA over time can help uncover these changes, obtaining cancer cells via traditional biopsy from tumors that have metastasized to other organs such as the bone can be both painful and difficult.

Liquid biopsies are a much less invasive way to measure the tiny amounts of DNA that are released from tumor cells into the blood. Ha and his team have developed new computational techniques, combined with whole gene sequencing, to reveal signatures of tumor DNA alterations from the blood.

“These signatures could allow clinicians to track whether a patient is responding well to treatment,” he said. “They could also help predict whether a patient’s tumor has the potential to resist treatment. Ultimately, our work will provide new tools to help doctors care for patients with less discomfort, better accuracy and greater precision.”

Ha came to Fred Hutch in 2018. This is his first award from the V Foundation. His other recent awards include a Transition Career Development Award from the National Cancer Institute/National Institutes of Health and a Young Investigator Award from the Prostate Cancer Foundation.

The V Foundation for Cancer Research grant program was founded in 1993 by Jim Valvano, a legendary basketball player, coach and broadcaster whose mission was “to achieve victory over cancer.” Valvano died of adenocarcinoma, a type of glandular cancer, in 1993. Since its creation, the Foundation has supported cancer research projects and related programs that are designed to change the course of cancer.



Comments

Post a Comment

Popular posts from this blog

I Wish I Didn't Need an Oncologist at All, But I'm Thankful for the One ...

-
Image
efudex side effects :: Article Creator Inmates Given Ivermectin In Jail Will Each Get $2,000 After Settlement Your browser is not supporteddetroitnews.Com detroitnews.Com wants to ensure the best experience for all of our readers, so we built our site to take advantage of the latest technology, making it faster and easier to use. Unfortunately, your browser is not supported. Please download one of these browsers for the best experience on detroitnews.Com Efudex Cream Efudex Cream Generic Name & Formulations General Description Fluorouracil 5%. Pharmacological Class Antimetabolite. How Supplied Soln (w. Drop dispenser)—10mL, 25mL; Crm—40g Efudex Cream Indications Indications Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling. Efudex Cream Dosage and Administration Adult Keratoses: Apply twice daily until eros
Read more

Early symptoms of cancer in males: Common warning signs

-
Image
fluciclovine f 18 :: Article Creator The U.S. Navy Might Be Done With The F/A-18 Super Hornet Fighter Will The U.S. Navy Receive Its Final F/A-18 Super Hornets? - Around the holidays, money can be tight, a fact that the United States Navy has also learned as its negotiations to buy the last batch of Super Hornets are reportedly stalled over the growing price tag. USNI News reported on Tuesday that the contract for the U.S. Navy to purchase the final twenty F/A-18 E/F Super Hornets from aerospace giant Boeing appears to be at a standstill. The Navy continues to work with Boeing on the contract for the 20 congressionally added Super Hornet aircraft. Ongoing contract negotiations cannot be discussed at this time," Capt. Michael Burks, the program manager for the F/A-18 and EA-18G office at Naval Air Systems Command, told USNI News in a statement. Previous estimates put the unit cost of the final batch of aircraft at $55.7 million, and la
Read more

20 Famous Men Who Have Had Prostate Cancer

-
Image
leukemia treatment options :: Article Creator Current And Breakthrough Treatments For Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is a slow-growing cancer of the immune system. Because it's slow-growing, many people with CLL won't need to start treatment for many years after their diagnosis. Once the cancer begins to grow, there are many available treatment options that can help people achieve remission. This means people can experience long periods of time when there's no sign of cancer in their bodies. The exact treatment option that you'll receive depends on a variety of factors. This includes: whether your CLL is symptomatic the stage of the CLL, based on results of blood tests and a physical exam your age your overall health While there's no cure for CLL yet, breakthroughs in the field are on the horizon. Doctors typically stage CLL using a system called the Rai system. Low
Read more