Kidney Disease Linked to Worse Prostate Cancer Surgery Outcomes - Renal and Urology News

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A study of patients undergoing radical prostatectomy found that those chronic kidney disease or end-stage renal disease have a higher risk of 30- and 90-day readmission and 1-year mortality.

Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) are at higher risk for worse postoperative outcomes after radical prostatectomy (RP) compared with patients without CKD, according to study findings presented at the American Urological Association 2020 Virtual Experience.

In an analysis of 2009 to 2015 data from 23,014 RP patients New York State, Olamide Omidele, MD, and colleagues at the Icahn School of Medicine at Mount Sinai in New York found that CKD patients had significant 3.7-fold increased odds of a long hospital stay, 4.4-fold increased odds of both 30-day and 90-day hospital readmission, and nearly 3.3fold increased odds of 1-year mortality in adjusted analyses compared with patients without CKD.

Patients with end-stage renal disease (ESRD) had nearly 1.8-fold increased odds of a long hospital stay, 1.6- and 1.8-fold increased odds of 30-day and 90-day hospital readmission, and 2.1-fold increased odds of 1-year mortality, the investigators reported.

Dr Omidele’s group also documented an increase in the proportion of RP patients with CKD or ESRD, which rose from 1.6% in 2009 to 3.6% in 2015.

“The results suggest that the number of patients undergoing radical prostatectomy with CKD or ESRD is increasing, and these patients are at significant risk for postoperative complication,” Dr Omidele said in a virtual presentation.

For the study, the investigators used data from the Statewide Planning and Research Cooperative System database, which is an all-payer statewide reporting system maintained by the New York State Department of Health. The study is the largest real-world cohort of patients with CKD and ESRD who have undergone RP, according to the investigators.

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Reference

Omidele O, Finkelstein M, Small A, Palese MA. The impact of chronic kidney disease and end stage renal disease on surgical outcomes after radical prostatectomy: A New York Statewide analysis. Presented at the American Urological Association 2020 Virtual Experience held in May. Abstract MP64-14.

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AUA 2020


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