Best DIM Supplements: Review Top Diindolylmethane Product Brands

Diindolylmethane supplements have surged in popularity in recent years.

Today, many people take diindolylmethane (DIM) supplements for testosterone, cancer, weight loss, acne, or hormones. As WebMD explains, DIM appears to help destroy cancer cells and reduce swelling.

Diindolylmethane sounds like a complex chemical. But it's not. Your body makes diindolylmethane on its own from a chemical called indole-3-carbinol, which is a natural component of broccoli, cauliflower, and other cruciferous vegetables.

Today, the best DIM supplements let you enjoy the benefits of diindolylmethane without requiring you to eat multiple heads of broccoli or cauliflower.

The Top Diindolylmethane (DIM) Product Brands in 2022

We're diindolylmethane (DIM) supplement experts. To compile the rankings below, our editorial team conducted hundreds of hours of research, contacted the best DIM supplement manufacturers, and pored over research studies.

After much deliberation, here's how we ranked the world's best diindolylmethane (DIM) supplements:

PrimeGenix DIM 3X
Cellucor P6 Ultimate GH
Provacyl
Hormonal Health HB5
Wejoy Balance
Brutal Force TBulk
Zhou DIM Active
Estrotase
We Like Vitamins DIM
Smoky Mountain Naturals (SM Nutrition) DIM
Nutricost DIM
EstroHalt
Genius Estrogen Balance
NatureBell DIM
Nature's Way DIM Plus
Truevantage DIM Elite
Zazzee DIM 300
Biote Medical DIM SGS+
MDacne DIM Skin Clearing
Purest Vantage DIM Supplement

PrimeGenix DIM 3X

PrimeGenix DIM 3X is a popular and well-rated DIM supplement that claims to reduce harmful estrogen and help regain your male edge – all with 100% natural ingredients.

Taking PrimeGenix DIM 3X daily can metabolize estrogen, improve mood and energy, and support testosterone production.

Like other DIM-based testosterone boosters, DIM 3X works by inhibiting the activity of the enzyme aromatase. That enzyme converts testosterone into estrogen in your body, raising estrogen levels and lowering levels of testosterone. As you age, this enzyme can become more active. PrimeGenix DIM 3X aims to block these effects.

Cellucor P6 Ultimate GH

Cellucor P6 Ultimate GH is a growth hormone supplement that uses DIM and other ingredients to target various hormones within your body.

Priced at $200 per bottle, P6 Ultimate GH is the Rolls Royce of DIM supplements. Cellucor describes the formula as the "world's most advanced GH support formula."

In addition to 100mg of DIM per serving, P6 Ultimate GH contains shilajit, L-arginine, velvet bean, apple extract, long jack, and other ingredients linked to testosterone, growth hormones, and other hormones. According to Cellucor, the supplement can boost testosterone, increase male vitality, and build lean muscle, among other benefits.

Provacyl

Provacyl is an all-natural HGH and testosterone booster that aims to help men fight male menopause. Taking Provacyl daily can raise testosterone levels, increase human growth hormone (HGH) production, and raise energy and sex drive.

Provacyl is also one of the few supplements on this list that claims to be doctor-recommended. According to the official website, at least one doctor recommends using Provacyl for its targeted benefits.

As men get older, they go through a version of menopause when testosterone levels drop, and estrogen levels rise. Andropause or male menopause can change your life. Provacyl aims to help.

Hormonal Health HB5

Hormonal Health HB5 is a favored weight loss formula. The supplement targets men and women who struggle to lose weight because of blocked hormones.

Over the years, your body could block certain hormones. Even if you're eating right and exercising, you may struggle to lose weight because of these blocked hormones.

Hormonal Health HB5 aims to help. According to the manufacturer, you can lose 1lb of fat every 48 hours when taking Hormonal Health HB5, rapidly transforming your body and making weight loss easy.

Wejoy Balance

Wejoy Balance is an all-natural menopause supplement that claims to reduce hot flashes and night sweats while contributing to healthy weight management, sleep quality, mood, stress, and anxiety.

Priced at $49 per bottle, Wejoy Balance is marketed to menopausal women who want help with symptoms.

While other DIM supplements only contain DIM, Wejoy Balance contains DIM mixed with green tea, fenugreek, ashwagandha, turmeric, and other traditional herbs and plants. Together, this unique combination could help support estrogen balance in your body.

Brutal Force TBulk

TBulk is a legal steroid supplement from Brutal Force. If you want to burn fat, build muscle, and transform your physique, then TBulk could help.

TBulk uses DIM and other ingredients to replicate the effects of Trenbolone, the popular steroid. According to Brutal Force, TBulk will accelerate lean muscle growth and ignite fat burning to help you build your best body – regardless of whether you're bulking or cutting.

DIM is the primary ingredient in TBulk. Other vital elements include pepsin powder, cat's claw extract, and beta-sitosterol. Together, this unique combination of ingredients can purportedly give you 100% safe, natural gains while building muscle and burning fat.

Zhou DIM Active

Zhou Nutrition has launched a popular DIM supplement called DIM Active. The Utah-based company delivers a supplement with 250mg of DIM per serving.

We like Zhou DIM Active because it complements its DIM dosage with broccoli seed extract and Bioperine (black pepper extract). The broccoli seed extract could raise levels of DIM in your body even further (broccoli is an excellent source of a chemical that your body converts to DIM). And Bioperine appears to boost the absorption of DIM, which means more of the active ingredients end up in your body.

Where Zhou DIM Active beats its competitors, however, is with the cost. At under $20 per bottle, DIM Active is one of the best-value DIM supplements on our list. Zhou DIM Active is tough to beat for pure DIM at a discount price.

Estrotase

Estrotase is a hormone balancer and natural aromatase inhibitor supplement that blocks estrogen to restore hormonal balance.

Priced at $50 per bottle, Estrotase can purportedly remove the type of estrogen that causes hormonal imbalances to occur. To do that, Estrotase contains a blend of zinc, Maca, Tongkat Ali, grape seed extract, DIM, kudzu root, and chrysin, all of which are popular in other hormone targeting supplements.

Each serving of Estrotase contains 100mg of DIM, which is linked to beneficial effects in studies. The Portland-based manufacturer advertises Estrotase primarily to bodybuilders.

We Like Vitamins DIM

We Like Vitamins DIM is a no-nonsense DIM supplement that contains 100mg of DIM per serving. While other DIM supplements advertise specific benefits or target certain people, We Like Vitamins DIM claims to help balance estrogen levels – a gift anyone can appreciate.

We Like Vitamins DIM is one of the best-value DIM supplements on our list. Each bottle contains 200 capsules or a 200 day supply. In terms of price-per-mg-of-DIM, We Like Vitamins DIM hits it out of the park.

We Like Vitamins makes its DIM in the United States. By taking it daily, you can help support healthy hormone and estrogen levels along with healthy menopause, among other benefits, according to We Like Vitamins.

Smoky Mountain Naturals (SM Nutrition) DIM

Smoky Mountain Naturals (SM Nutrition) makes one of the internet's most popular DIM supplements. Featuring 200mg of DIM per serving, it's also one of the more powerful DIM formulas on our list.

Priced at just $20 per bottle, Smoky Mountain Naturals DIM is backed by 19,400+ reviews and an average rating of 4.4 stars out of 5 on Amazon.

According to the manufacturer, the supplement can help balance hormones, metabolize excess estrogen, help with menopause, and inhibit aromatase, among other benefits.

Nutricost DIM

Nutricost DIM is a DIM supplement with 300mg of diindolylmethane per serving. Each bottle contains a four-month supply of DIM (or a two-month supply if you double the dosage).

Plus, Nutricost has added Bioperine to its DIM formula to enhance absorption. That means more of the DIM ends up in your body instead of being excreted.

If you want the maximum dose of DIM per capsule, then Nutricost DIM is one of the best options on our list. Each capsule contains 300mg of DIM and 5mg of Bioperine for maximum effects. Nutricost makes the formula in a GMP-compliant, FDA-registered facility.

EstroHalt

EstroHalt is a nutritional supplement that claims to support estrogen metabolism in the form of a convenient tablet. The supplement is primarily marketed as an estrogen blocker, helping with everything from PCOS to menopause to PMS and more.

Each serving of EstroHalt contains 150mg of DIM, 50mg of indole-3-carbinol, and 50mg of flaxseed oil. While other DIM supplements only contain DIM, EstroHalt also contains indole-3-carbinol, the natural chemical in cruciferous vegetables that gets converted to DIM within your body. That means you get DIM from two angles.

With 60 pills per bottle and a price of $26.99, EstroHalt continues to be a popular option for people seeking to balance estrogen for all different reasons.

Genius Estrogen Balance

Genius Estrogen Balance is The Genius Brand's contribution to the DIM supplement space. Each bottle of Genius Estrogen Balance contains 30 veggie capsules of DIM to block estrogen, manage cortisol, and support thyroid health, among other benefits.

Instead of only containing DIM, Genius Estrogen Balance includes 150mg of DIM mixed with 150mg of grape seed extract and 5mg of Bioperine. That means you can maximize absorption while also inhibiting aromatase with grape seed.

Grapeseed is a natural ingredient with similar effects to DIM but works differently. Grape seed may inhibit aromatase naturally, helping block the conversion of testosterone into estrogen. Genius Estrogen Balance is one of the few DIM supplements that use this unique combination, and it's well-rated for that reason.

NatureBell DIM

NatureBell DIM is a diindolylmethane supplement that combines pure DIM with broccoli and black pepper extract. At $22 per bottle (180 capsules per bottle), it's a good value supplement that doesn't compromise quality or dosage.

NatureBell claims its 3-in-1 formula is better for absorption because of its black pepper extract. You also get one of the highest dosages of DIM on this list, with each capsule of NatureBell DIM containing 300mg of DIM.

Plus, by adding broccoli powder to the supplement, NatureBell has given your body an additional source of DIM. Your body converts a natural chemical in broccoli into DIM, which means more DIM and better benefits.

Nature's Way DIM Plus

Nature's Way DIM Plus is an estrogen metabolism formula designed for enhanced absorption. Backed by 4,000+ Amazon reviews and an average rating of 4.6 stars out of 5, Nature's Way DIM Plus is one of the internet's best-rated major DIM formulas.

Each Nature's Way DIM Plus capsule contains 100mg of DIM and 100mg of a vegetable blend with spinach, broccoli, and cabbage. By giving you condensed versions of cruciferous vegetables, Nature's Way DIM Plus can provide an additional source of DIM beyond the pure DIM inside each capsule.

We also like Nature's Way DIM Plus because it uses a unique DIM formula called Indolplex. That professionally-formulated version of DIM can enhance the effects further, helping more DIM end up in your body.

Truevantage DIM Elite

Truevantage DIM Elite is a DIM supplement with 250mg of DIM per serving, making it one of the more powerful options on our list.

To enhance the effects of this DIM, the manufacturer has added black pepper extract (for absorption) along with Dong Quai and natural vitamin E.

By taking one or more capsules of Truevantage DIM Elite daily, you can purportedly support menopause relief, PCOS treatment, hormonal acne, and hormonal balance, among other benefits.

Zazzee DIM 300

Zazzee DIM 300 is an extra-strength formula from Zazzee Naturals that contains 300mg of DIM with 10mg of Bioperine.

Each serving of Zazzee DIM 300 contains a strong dose of DIM for under $19 per bottle. Plus, Zazzee has added pure, organic broccoli to the formula. Each capsule contains 100mg organic, pure broccoli, including the bud and stalk, to boost DIM absorption into the body.

The makers of Zazzee DIM 300 claim the formula offers 30% enhanced absorption, 100 capsules per bottle, and 10mg of black pepper extract.

Biote Medical DIM SGS+

Biote Medical DIM SGS+ is a popular DIM supplement that claims to detoxify the body, regulate estrogen, and control appetite, among other benefits.

With 60 capsules per bottle and 300mg of DIM per serving, Biote Medical's DIM SGS+ combines DIM with an ingredient we don't see in other formulas: pomegranate extract. There's also the tried-and-true broccoli extract, which contains a natural component that gets converted into DIM within your body.

While each serving of DIM SGS+ contains 300mg of DIM, each capsule of DIM SGS+ includes 150mg of DIM in crystalline form along with 100mg of pomegranate extract. Overall, you get a strong dose of DIM and pomegranate extract – albeit at a slightly higher cost than other DIM supplements.

However, Biote Medical's DIM SGS+ has one of the best Amazon ratings on this list: with 900+ reviews, DIM SGS+ has a nearly perfect rating of 4.8 stars out of 5.

MDacne DIM Skin Clearing

MDacne Customized Skin Clearing Supplements is a customized skin-clearing supplement that, unlike most DIM supplements on our list, is specifically designed to help treat hormonal acne.

Some studies suggest DIM can help with hormonal acne. Hormonal imbalances can cause acne. If your acne is flaring up because of hormones, then a DIM supplement could help.

Each bottle of MDacne DIM Skin Clearing contains DIM mixed with cruciferous extracts, helping you get your maximum daily recommended serving of diindolylmethane.

However, one of the most significant advantages of MDacne's Customized Skin Clearing Supplements is a dermatologist-developed it. That gives MDacne's formula more legitimacy than competing DIM supplements on our list.

Purest Vantage DIM Supplement

Purest Vantage DIM is a straightforward DIM supplement designed to balance hormones in men and women. It's also advertised as a menopause and estrogen support formula.

Priced at $16.95 per bottle, Purest Vantage DIM is one of the cheapest formulas on our list. It also contains 250mg of DIM per capsule, one of the best doses-per-capsule on our list. You also get 50mg of Dong Quai and 5mg of Bioperine.

The Orlando-based manufacturer advertises DIM to support hormone balance using a proven natural chemical (DIM) blend with a traditional Asian remedy (Dong Quai). Together, this unique combination can help support hormones in various ways. There's also vitamin D, which your body needs for hormone production.

How We Ranked The Top Diindolylmethane (DIM) Product Brands

Every diindolylmethane (DIM) supplement claims to give you a high-quality source of DIM. However, not all supplements are made equal. There's a vast difference between cheap and high-end DIM supplements.

To separate the best and worst DIM supplements, we used the following ranking factors:

DIM Dosage

All DIM is pretty much the same. The quality doesn't matter, but the dosage does. Most DIM studies involve a dosage of 100mg to 900mg. We focused primarily on DIM supplements that used 100mg or more. Studies suggest that DIM works at doses as low as 100mg, although it could work more effectively at 300mg and higher doses. Most DIM supplements used a dose of around 100mg, with some of the higher-ranked DIM formulas using dosages of 150mg, 250mg, or even 350mg per capsule.

Science-Backed Formulas

DIM has been proven to help support estrogen balance in some studies. Good DIM supplement companies cite large, human trials to validate the DIM inside each formula. Some of the best DIM supplement companies even perform direct clinical trials on their formulas to verify they work. The more evidence a company could cite to support its formula, the higher we ranked it.

Ease of Use and Capsule Quality

Nobody wants to swallow a horse tranquilizer-sized capsule to get their daily dose of DIM. We considered ease of use and capsule quality in our rankings. We disliked DIM supplements that used cheap gelatin to create the capsule, and we preferred supplements that used veggie capsule ingredients. The easier a formula was to use, the higher we ranked it.

Price & Value

Like any trendy supplement space, the DIM supplement space is booming with excellent and poor products. Some supplements are priced high with no justification. Others are priced low yet offer good value. We believe you should get an ideal DIM supplement on a tight budget, and we also think you should get premium ingredients for a premium price tag.

Advertised Benefits

Although many people use diindolylmethane (DIM) to target cancer, DIM supplement companies cannot claim to cure, treat, or prevent any disease – including cancer. We were wary of supplement companies that advertised DIM supplements as a cure or even hinted about it. If a company is willing to ignore FDA rules on advertised benefits, they're eager to cut corners in product quality.

Complementary Ingredients

We primarily judged supplements based on their dosage of DIM. However, we also considered complementary ingredients in our rankings – mainly if the supplement targeted growth hormone or testosterone production. Some DIM supplements contain libido boosters, blood flow enhancers, and other ingredients linked to hormone production.

Manufacturer Reputation & Transparency

Some manufacturers have a reputation for creating high-quality supplements. Others are new and have a limited track record. We preferred manufacturers with a proven reputation for producing high-quality supplements over the years.

Doctor Recommended or Made by a Medical Advisory Board

The best DIM supplements are recommended by doctors or, at least, were formulated by a medical advisory board. Some of the world's best supplement companies maintain a medical advisory board to ensure safety and efficacy. The more professionals created a specific DIM supplement, the higher we ranked it.

What is a DIM Supplement?

A diindolylmethane (DIM) supplement contains a concentrated form of DIM.

DIM is a natural compound your body creates after eating cruciferous vegetables – like broccoli, cauliflower, and Brussels sprouts.

Research suggests DIM can interact with estrogen, which could cause various effects throughout the body. For example, some people take DIM for hormonal changes, while others take DIM for hormone-specific cancers.

What Are the Best Sources of DIM?

The best sources of DIM are cruciferous vegetables and DIM supplements.

Add more DIM to your diet with broccoli, cauliflower, kale, and Brussels sprouts. Or, buy any of the top-ranked DIM supplements listed above.

If you aren't getting enough cruciferous vegetables in your diet, then DIM supplements may help.

Cruciferous vegetables don't technically contain DIM: they have a natural chemical called indole-3-carbinol that appears to be linked to DIM. As your body breaks down this natural chemical, it creates DIM, raising DIM levels in your body.

Benefits of DIM Supplements

Early studies suggest DIM supplements may support all of the following benefits:

Testosterone
Anticancer effects, particularly for hormone-linked cancers like breast and prostate cancer
Weight loss
Acne
Symptoms of menopause
Symptoms of PMS

Some studies also suggest DIM helps with inflammation, general hormonal balance, sleep, stress management, and more.

How Does DIM Work?

To understand how DIM works, you first need to understand we have two types of estrogen in our bodies: good and bad estrogen.

Good estrogen helps protect the heart and brain, floods your body with inflammation-controlling antioxidants, promotes cell growth, and encourages cell renewal while getting rid of damaged cells.

Bad estrogen, meanwhile, appears to cause cancer. People who are obese and those with high levels of inflammation tend to have higher levels of bad estrogen. Free radicals cause inflammation and raise levels of bad estrogen within your body.

DIM appears to swing the balance in favor of good estrogen. When you take DIM, it helps to metabolize good estrogen while decreasing bad estrogen. DIM also inhibits aromatase, the enzyme that converts testosterone into estrogen.

Diindolylmethane (DIM) Supplement Benefits: What Does Science Say?

Diindolylmethane (DIM) research is limited. However, early studies on DIM are promising.

Many early studies on DIM focused on its ability to target estrogen. DIM appears to balance estrogen levels in the body, for example. Some studies suggest DIM can also stimulate the production of a less potent, more beneficial form of estrogen called 2-hydroxy estrone.

Eventually, one study found a connection between DIM and a more robust form of estrogen called 16 alpha-hydroxy estrone. This type of estrogen is linked to weight gain and increased risk of certain cancers, including breast cancer and uterine cancer.

Your body uses an enzyme called aromatase to convert testosterone into estrogen. Many testosterone supplements work by inhibiting aromatase, helping stop the body from converting testosterone (a crucial male sex hormone) into estrogen. In this study, researchers found DIM inhibited the aromatase enzyme, which could prevent your body from turning testosterone into estrogen.

Over the years, studies have increasingly explored the anticancer effects of DIM. For example, in this study, researchers found evidence in test tubes and animal cells that DIM could help prevent the growth and spread of breast cancer cells. In a yearlong follow-up study, researchers gave 130 women with breast cancer a placebo or 150mg of DIM twice per day. Both groups of women were receiving tamoxifen therapy. Researchers found that DIM supplements led to significant improvements in the ratio of two types of estrogen, including 2-hydroxy estrone and 16-hydroxy estrone. Adjusting this ratio could reduce the risk of breast cancer and create anti-tumor effects.

In a separate study, researchers gave 108mg of DIM per day to a group of 19 post-menopausal women with early-stage breast cancer. They found DIM led to beneficial changes in estrogen levels.

Other studies suggest DIM can help with more than just breast cancer. In this 2018 study, for example, researchers found that DIM suppressed ovarian cancer cell visibility and metastasis while enhancing chemotherapy sensitivity. This 2016 study showed that DIM helped with gastrointestinal cancer by encouraging the death of cancer cells and increasing the efficacy of other drugs.

Meanwhile, this 2014 study found that DIM was associated with multiple therapeutic effects on prostate cancer cells. A separate study found that DIM could help combat prostate in intraepithelial neoplasia (PIN), which is linked to the growth of prostate cancer cells and could be a precursor to prostate cancer. To assess the effects of DIM on prostate cancer cells, researchers told a group of 21 men with early warning signs of prostate cancer (high-grade PIN) to take either a placebo or 900mg of DIM per day. The group of men taking DIM experienced significant improvements in prostate health and better PIN biomarkers.

It's not all good news for DIM and cancer: some studies have found no correlation between certain types of cancer and DIM. In one of the most extensive DIM studies to date, researchers told a group of 551 women with cervical abnormalities to take 150mg of DIM per day. Re...