The Tale of a Rubbery White Clot: Poorly Differentiated Spindle Cell Sarcoma Presenting As Superior Vena Cava Syndrome - Cureus
Sarcoma is an uncommon neoplasm of mesenchymal origin (1). The presentation is usually vague. It may present as a mass in the thigh or retroperitoneum, with resultant pain or paresthesia of the affected area. The diagnosis is very challenging due to its indistinct presentation. The prognosis remains poor due to delays in diagnosis and few available therapeutic options. We herein report the first case of superior vena cava (SVC) syndrome caused by spindle cell sarcoma. Introduction Sarcoma is a heterogeneous collection of malignant tumors of mesenchymal origin that is extremely rare. It accounts for less than 1% of all adult cancers [1]. The cause of most sarcomas is unknown. Genetic predispositions [2], such as Li-Fraumani syndrome, neurofibromatosis type 1, and retinoblastoma; radiation therapy or chemotherapy exposure; carcinogen exposure; chronic irritation, lymphedema, human immunodeficiency virus, and human herpesvirus 8, are some of the known correlati...