Diverticulitis and colon cancer: Symptoms, causes, and more
Simple Blood Tests Could Be The Future Of Cancer Diagnosis
Around four years ago, now 77-year-old John Gormly went for what was supposed to be a routine blood test. But the results were life-changing.
The test suggested Gormly had colon cancer, which a colonoscopy later confirmed was Stage 2, meaning the cancer had spread through the wall of the colon but not to his lymph nodes.
"I thought [my doctor] was wrong," Gormly, CEO of a construction company near Newport Beach, California, told Live Science. "I go, 'Nah, I don't feel anything.' But there it was. It was real; the colonoscopy showed it."
Gormly was one of the first patients to take a newly approved test called Shield, which its makers say can detect colon cancer from a blood sample. After his diagnosis, Gormly had surgery to remove the tumor and was back to work within 10 days.
Science Spotlight takes a deeper look at emerging science and gives you, our readers, the perspective you need on these advances. Our stories highlight trends in different fields, how new research is changing old ideas, and how the picture of the world we live in is being transformed thanks to science.An early version of Guardant Health's Shield test has been commercially available since 2022, but it wasn't covered by insurance. However, after approval from the U.S. Food and Drug Administration (FDA) in July 2024, a diagnostic version of Shield was launched commercially and is now covered by Medicare.
Shield is only a blood drop in an ocean of emerging "liquid biopsies."
Scientists have developed blood tests for several cancers, including those of the breast, pancreas and stomach. Some blood tests even detect multiple types of cancer. If these liquid biopsies can be rolled out widely, they could help detect cancer earlier, more easily, or with fewer invasive measures — which, in turn, could lead to earlier detection and fewer cancer deaths.
But many of these tests are still in their early stages. They often detect a lower fraction of cancer cases than gold-standard screening tools like colonoscopies do, meaning they will likely supplement, rather than replace, traditional screening methods. Others may have unacceptable rates of "false positives," meaning a person is initially told they have cancer but diagnostic follow-ups show they do not. This can lead to needless worry or additional invasive tests. These include traditional biopsies, which involve removing tissue samples via needles or surgery. And for some diseases, it's not clear that early diagnosis on a blood test will lead to better outcomes.
However, as these kinks are ironed out, it's likely that blood-based cancer screening will become a normal part of our medical care — one that has the potential to improve cancer outcomes dramatically, experts say.
John Gormly went in for a routine blood test and learned he likely had colon cancer. After follow-up diagnostic tests and a relatively simple surgery to remove the cancer, he is now in remission. (Image credit: Guardant Health) Simplifying screeningGormly's doctor recommended a Shield test after noticing that Gormly hadn't had a colonoscopy in a while. He's not alone. Current recommendations suggest that people ages 45 to 75 who are at average risk of colon cancer get a screening, such as a colonoscopy or a stool-based test, every five to 10 years. Yet around 1 in 3 of these people have never been screened.
That's a problem, because colon cancer is the fourth-most-common cancer. Experts have argued that early detection could eliminate 90% of colon cancer deaths. It typically takes around 10 years for early, precancerous growths like polyps to morph into deadly cancer cells, and if these cells are caught early, they can easily be removed.
Despite the potential for early diagnosis and cure, many people avoid these screenings. This may be one reason colon cancer is the second-most-common cause of cancer death.
People avoid screenings for many reasons, said Dr. William Grady, a professor of translational science and therapeutics at the Fred Hutchinson Cancer Center in Seattle who helped lead the Shield trials. Some people feel embarrassed during screenings such as colonoscopy or fear that it may be painful, he told Live Science. Those opting for colonoscopy may struggle to get time off work, whereas others may dislike the idea of handling stool for a stool-based test, he said.
"That's why there's an opportunity for blood tests that is really powerful because people are inclined to do blood tests; they're convenient and can be done during a health care encounter," Grady said.
Shield works by detecting small DNA fragments that are released into the blood from colon cancer cells or precancerous cells called adenomas, a type of polyp. The test also picks up on subtle differences between cancerous cells and normal cells in chemical tags on DNA known as methyl groups.
In a paper published in March 2024 in The New England Journal of Medicine, Grady's team showed that Shield detected 83% of colonoscopy-confirmed colon cancer cases in a cohort of almost 10,000 people. It also had a false positive rate of 10%.
Because Shield detects a smaller percentage of colon cancer cases than stool-based tests (92%) or colonoscopies (95%) do, it won't replace those diagnostic tests, Grady said. However, it could expand the number of screening options available to patients, he added. This additional option may improve screening compliance, which could lead to earlier disease detection and thus a reduction in colon cancer deaths.
The Shield test is approved for use every three years, Grady said. However, current studies are investigating whether it would be more accurate if it were done every year or two, he added.
If Gormly's cancer had spread to the rest of his body, it would have been much harder to treat. People whose colon cancer is caught at Stage 2, like Gormly, have an 85% chance of living at least another five years. By Stage 4, when it has spread throughout the body, those odds go down to just 10%.
"That could have been the end of me, so it [Shield] definitely changed my life," Gormly said.
A researcher working in the Shield blood testing laboratory. Guardant's test for colon cancer was FDA-approved in 2024. (Image credit: Guardant Health) Accelerating diagnosisPancreatic cancer is another disease that could benefit from a blood-based diagnostic test. Unlike colon cancer, pancreatic cancer is relatively uncommon, affecting 1 in 56 men and 1 in 60 women. Yet pancreatic cancer is the third-most-common cause of cancer death in the U.S.
That's because, by the time most people notice symptoms, such as abdominal pain or discomfort, the disease is already very advanced, said Ajay Goel, a professor and chair of the Department of Molecular Diagnostics and Experimental Therapeutics at the Beckman Research Institute of City of Hope in Duarte, California.
There is no broad-based screening program in the U.S. For people at average risk of pancreatic cancer. Later stages of the disease are easily detectable via MRI or CT scan, Goel told Live Science. But by that point, the five-year survival rate is extremely low: around 3% once the cancer has spread throughout the body, compared with 44% if it is still limited to the pancreas. Once cancer has spread beyond the pancreas, surgical removal is usually no longer possible, and treatments such as chemotherapy and radiotherapy are minimally effective.
A potential solution is a new blood test developed by Goel's team. It aims to detect early-stage pancreatic cancer by identifying small cancer-specific molecules called microRNAs. These molecules regulate whether genes are switched on or off and are found in the blood of patients with early-stage disease, as well as inside exosomes, which are tiny packages that cancer cells release into the blood.
In a study of nearly 1,000 people, the test (which is still unnamed) detected between 88% and 93% of early- and late-stage pancreatic cancer cases, using blood drawn from people in the U.S., South Korea and China. When the test was modified to also measure the amount of a protein known as CA-19 in the blood, it picked up 97% of early-stage cases in the U.S. Group. CA-19 is a known biomarker of pancreatic cancer, but on its own, it is not reliable enough to be used for diagnosis. When combined with CA-19 detection, the new test had a 5% to 10% false positive rate, Goel said.
The findings, which haven't been peer-reviewed yet, were presented at the 2024 American Association for Cancer Research Annual Meeting in San Diego.
"If you can find more and more of these cancers early on, there is a hope that many of these patients can be cured," Goel said.
The team envisages the test being taken yearly — for instance, when patients see their doctor for an annual physical exam. However, in those who have a family history of pancreatic cancer, it may make sense to test more frequently — perhaps every six months, Goel said.
If you can find more and more of these cancers early on, there is a hope that many of these patients can be cured.
Ajay Goel Multicancer detectionScientists are also developing multicancer detection (MCD) tests that screen for many types of cancer at once. MCD tests differ slightly in the types of cancer they detect and how they do it. But like many of the single-cancer detection tests, MCD tests look for cancer-specific molecules, such as tumor DNA, but on a larger scale. Some MCD tests sample urine or another bodily fluid in addition to blood.
In theory, such tests could not only provide a less-invasive approach to screening but also reduce the number of tests a person has to take at once. However, most of these tests are still in early development. The ones that are farther along, such as Grail's Galleri and Exact Sciences' Cancerguard, have not received FDA approval yet. And some experts have argued that the tests' efficacy claims are overhyped.
Even if MCD tests do work and they become more affordable (Galleri, for example, currently costs around $950), experts still aren't sure of the best way to use them. "There's this belief that if we could only detect all cancers early, we would solve the cancer problem," Ruth Etzioni, a professor at Fred Hutchinson who was not involved in Grady's work with Shield, told Live Science. But sometimes there is no good treatment for early cancers, so catching them ahead doesn't necessarily lead to improved outcomes.
And there's always a risk of false positives. After taking an MCD test, patients may wait up to six months to know one way or the other, Dr. Jennifer Croswell, a medical officer at the National Cancer Institute, told Live Science. There may be many reasons for this delay, including that it takes time to perform multiple rounds of follow-up testing to figure out which organ is affected, she said. There are also currently no evidence-based clinical guidelines that tell doctors the best way to follow up on positive results from MCD tests, Croswell said. Consequently, these tests may create uncertainty for patients.
The way forwardWhile many diagnostic blood tests for cancer are still in the pipeline, at least some of these tests will likely affect diagnosis and treatment in the next several years. For instance, Goel and colleagues are now running a clinical trial to see if their test can detect early-stage pancreatic cancer in high-risk individuals who have not yet been diagnosed. If it's successful, they intend to test it in the general population.
"I think if things go well, we foresee that probably in the next two to four years, this test should be on the marketplace to be used for early detection of pancreatic cancer worldwide," Goel said.
Meanwhile, Grady's team is planning to investigate whether Shield helps get more people screened for colon cancer who are often missed, such as underrepresented minority groups or those who live in areas with restricted health care access.
Shield is "the first of, I think, a whole series of tests that we're going to be seeing coming up for screening for not only colon cancer but also for breast cancer, lung cancer, liver cancer," Grady said.
Four years later, tests show Gormly is cancer-free. He hopes his experiences help others who may be tempted to skip colon cancer screening.
"I hope that as a result of this [speaking up]," he said, "someone else tries it and has the same success I did."
New Cancer Tests Make Early Detection Easier
If detected early, cancer is much easier to treat. Emerging non-invasive tests can help early diagnosis.
As diseases go, cancer is deadly. Its early detection, however, can make a huge difference to the patient's life. Early diagnosis can help prevent metastasis, which is the spread of the cancer to other parts of the body. It improves the chances of successful treatment, reduces treatment costs, and increases survival rates. When detected early, cancer is also often treatable with less aggressive methods such as targeted therapies, immunotherapy and active surveillance. These make the patient's quality of life better than the more aggressive alternatives, surgery and chemotherapy.
Given all this, the emergence of liquid biopsy for cancer screening is good news for cancer patients.
Different cancers require specific screening tests to detect abnormalities before symptoms appear. Some of the most commonly used screening methods include mammograms, which use X-rays to detect breast cancer; pap smears and HPV tests, which screen for cervical cancer; and colonoscopy, along with stool-based tests, to identify colorectal cancer.
Unlike traditional biopsies, which require the removal of tissue samples, liquid biopsy is a non-invasive approach that analyses biomarkers-biological indicators of disease-in bodily fluids such as blood, saliva, and urine. This allows doctors to detect cancer at an early stage, monitor how a patient responds to treatment, and identify minimal residual disease, which refers to small amounts of cancer cells that remain after treatment and could potentially lead to a relapse.
The method relies on several biomarkers to detect cancer. For example, tiny fragments of genetic material known as circulating tumour DNA or ctDNA are released by cancerous cells into the bloodstream. There are also circulating tumour cells, meaning cancerous cells that have broken away from the tumour and are found in the blood. Liquid biopsies look for both.
Other such biomarkers include extracellular vesicles and exosomes, which are small particles released by cells that contain genetic material and proteins, as well as microRNAs, proteins, and metabolites, all of which can provide critical information about cancer presence.
Some liquid biopsy tests have already received FDA approval for clinical use. Examples include Guardant360 CDx, FoundationOne Liquid CDx and the ExoDx Prostate Test.
AI and personalised medicineOngoing clinical trials are currently refining liquid biopsy technology.
Researchers at the University of Queensland have developed a blood test to detect early-stage ovarian cancer, demonstrating a 94 percent accuracy rate with a false-positive rate of only 4 percent, meaning it rarely misidentifies healthy individuals as having cancer.Another promising study, known as the EXONERATE study, is investigating a liquid biopsy method to predict progression-free survival, overall survival, and treatment response rates in patients with metastatic colorectal cancer, a form of advanced colon cancer that has spread to other parts of the body.
Saliva-based liquid biopsy is also emerging as a promising tool for detecting and monitoring cancers of the oral cavity, head, neck and lungs. By analysing tumour DNA, RNA, proteins and exosomes in saliva, doctors can detect early signs of cancer using a simple, non-invasive test.
Several key biomarkers are being studied in this method, including mutations in certain genes which are commonly associated with cancer development.
Compared to traditional biopsies, saliva-based tests are painless, cost-effective, and allow for continuous cancer tracking, making them a valuable tool in personalised medicine. As this technology advances, costs are expected to decrease, improving accessibility.
Additionally, artificial intelligence is helping to refine these tests by reducing false positives, minimising overdiagnosis and improving overall accuracy.
Liquid biopsy is also transforming personalised medicine by enabling real-time, non-invasive cancer monitoring, guiding targeted therapy decisions, and predicting how well a patient will respond to treatment.
Personalised medicine, also known as precision medicine, is an approach that tailors treatment based on an individual's unique genetic makeup, lifestyle and environment. Rather than applying a "one-size-fits-all" approach, doctors use genetic information to determine the most effective course of treatment.
In cancer treatment, genetic testing can identify specific mutations which are linked to breast cancer or lung cancer. This information allows doctors to prescribe targeted therapies that attack cancer cells more precisely, reducing side effects, as compared to traditional chemotherapy.
Personalised medicine is also being applied in pharmacogenomics, a field that studies how a person's genetic profile affects their response to medications. By understanding genetic variations, doctors can predict which drugs will work best for a patient while reducing the risk of adverse reactions.
As genomics, AI, and molecular biology continue to advance, personalised medicine is reshaping healthcare by improving early disease detection, tailoring treatments to individual needs, and ultimately improving outcomes for patients.
Who should get tested?While the emergence of new methods for cancer screenings is invaluable in detecting cancer early, the need for such screenings depends on individual risk factors, medical history, and discussions with healthcare providers.
One of the key challenges of cancer screening is the potential for false positives, where a test incorrectly suggests the presence of cancer, leading to unnecessary stress and additional medical procedures. Overdiagnosis is another concern, as some screenings detect slow-growing cancers that may never cause harm, resulting in unnecessary treatment. Some cancers are so slow-growing that we can live with them without them killing us; they are indolent. This is famously true for both prostate cancer and thyroid cancer.
Most people do not require cancer screenings until their forties, as the risk of developing cancer increases with age due to genetic, lifestyle, and environmental factors. However, certain individuals face a higher risk and may require earlier or more frequent screenings.
Those with a family history of cancer or inherited genetic mutations have a significantly increased risk of developing cancer. Additionally, lifestyle factors such as smoking, heavy alcohol consumption, obesity, and physical inactivity increase the chances of developing cancers like lung, liver, breast, and colorectal cancer. Exposure to harmful chemicals, radiation, and chronic conditions such as diabetes, inflammatory diseases, and HPV infection can also heighten the risk of cancer.
Women with hormonal risk factors, such as late menopause, early menstruation, or having children later in life, face an increased likelihood of developing breast and endometrial cancer, while men over 50 are more susceptible to prostate cancer.Dietary habits also play a role, as consuming high amounts of processed meats and red meats has been linked to colorectal cancer.
Maintaining a healthy lifestyle, avoiding known carcinogens and undergoing screenings if one is at risk can significantly reduce the danger of cancer.
Dr Tatini Rakshit is an Assistant Professor at Shiv Nadar Institution of Eminence, Delhi-NCR, and a former Postdoctoral Fellow of the National Cancer Institute, National Institute of Health, USA.
Originally published under Creative Commons by 360info.
The post New cancer tests make early detection easier appeared first on 360.
Katie Thurston Reveals Breast Cancer Has Spread To Liver After Diagnosis
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Katie Thurston has shared an update after revealing earlier this month that she was diagnosed with breast cancer.
The former Bachelorette star, 34, took to Instagram on Friday and shared that after undergoing some tests, she learned that her breast cancer has spread to her liver.
"It is fairly small," she said. "However, that does put me at stage four. But as of now, my new treatment plan is going to start next Friday. It does involve chemo."
Thurston began her video by addressing questions about why she hasn't started treatment yet, 43 days after her diagnosis.
Former Bachelorette Katie Thurston reveals what led to breast cancer diagnosis
In the caption of the video, she wrote, "There is a lot of testing and prep that goes into cancer treatment."
"One important test is checking to see if the cancer has metastasized (spread)," she added and said in the video that she underwent a CT scan, bone density scan, blood work and MRI. She also underwent a PET scan.
"What's great about a PET scan is that sometimes it can detect things that some of the other tests did not," Thurston said.
She continued, "Unfortunately, in my case, it did detect some spots on my liver that were a little suspicious. Because of this, I did have to then do a liver biopsy to see if my cancer has spread."
"After days of waiting, unfortunately, I did find out today that my breast cancer has spread to my liver," she added.
Earlier this month, Thurston revealed to ABC News that she was diagnosed with Stage 3 triple positive ductal carcinoma, a type of cancer where tumor cells have estrogen receptors, progesterone receptors, and HER2 receptors on their surface, according to the U.S. National Cancer Institute.
She learned about her diagnosis in February, just a few months after she became engaged to comedian Jeff Acuri.
Earlier this week, Thurston revealed that she and Acuri tied the knot on March 22 in an intimate backyard ceremony at their home.
'Bachelorette' alum Katie Thurston marries comedian Jeff Arcuri following breast cancer diagnosis
PHOTO: Reality TV Personality Katie Thurston attends Stephen Lovegrove's First Noelle Ball 2022. (Paul Archuleta/Getty Images)
Thurston said she chose to harvest her eggs following her diagnosis in case she and Acuri try to have a child together in the future.
Despite what she is going through, Thurston said she is staying positive.
"I know stage four can sound very scary and it can be, however, given that I am triple positive and the spots on my liver are fairly small and detected early, I feel very optimistic on my outcome," she said.
"I'm very confident in the team at Columbia, and I just wanted to share that update," she added.
In her interview with ABC News, Thurston said that she hopes sharing her story encourages others to "be proactive" and "get checked out."
"You could be doing yourself a favor in the future," she said.
Katie Thurston reveals breast cancer has spread to liver after diagnosis originally appeared on goodmorningamerica.Com
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