PET Molecular Imaging Improves Disease-Free Survival in Prostate Cancer Treatment - DocWire News

-
SABR, Exercise Might Help Patients with Prostate Cancer Who are About to Start Treatment
Exercise Might Help Patients with Prostate Cancer Who are About to Start Treatment

Adding positron emission tomography (PET) molecular imaging to conventional cancer screening guided treatment decisions that led to improved disease-free survival (DFS) among men with recurrent prostate cancer, according to findings presented at the virtual American Society for Radiation Oncology 2020 Annual Meeting.

The phase II/III EMPIRE-1 (Emory Molecular Prostate Imaging for Radiotherapy Enhancement) trial, enrolled 165 patients with recurrent prostate cancer following prostatectomy. Participants were randomized to either radiation therapy based on conventional screening or treatment based on imaging with the fluciclovine PET radiotracer, a molecular imaging agent. The primary endpoint was failure rate at three years. The main goal of the investigation was to use the advanced molecular imaging to improve post-prostatectomy decision making regarding whether to deliver radiotherapy and optimize where radiation is received.

The three-year DFS rate was 75.5% among patients who underwent the molecular imaging compared with 63% among those who received conventional imaging alone (P=0.003). The DFS benefit persisted at four years in the PET scan group (75.5% vs. 51.2%; P<0.001). There were no significant differences in severe genitourinary or gastrointestinal adverse effects between the two groups.

“At three years, the group getting treatment guided by PET fluciclovine had a 12% better cancer control rate, and this persisted at four years as well, with a 24% improvement,” said study leader Ashesh B. Jani, MD, in a press release. “We think the improvement was seen because the novel PET allowed for better selection of patients for radiation, better treatment decisions, and better radiation target design.”

The same investigators will conduct a second trial, EMPIRE-2, to assess the efficacy a new type of advanced molecular imaging, prostate-specific membrane antigen PET. The novel radiotracer targets a receptor on the surface of prostate cancer cells and could potentially be even more effective than fluciclovine in guiding treatment decisions for patients with prostate cancer.



Comments

Post a Comment

Popular posts from this blog

I Wish I Didn't Need an Oncologist at All, But I'm Thankful for the One ...

-
Image
efudex side effects :: Article Creator Inmates Given Ivermectin In Jail Will Each Get $2,000 After Settlement Your browser is not supporteddetroitnews.Com detroitnews.Com wants to ensure the best experience for all of our readers, so we built our site to take advantage of the latest technology, making it faster and easier to use. Unfortunately, your browser is not supported. Please download one of these browsers for the best experience on detroitnews.Com Efudex Cream Efudex Cream Generic Name & Formulations General Description Fluorouracil 5%. Pharmacological Class Antimetabolite. How Supplied Soln (w. Drop dispenser)—10mL, 25mL; Crm—40g Efudex Cream Indications Indications Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling. Efudex Cream Dosage and Administration Adult Keratoses: Apply twice daily until eros
Read more

Early symptoms of cancer in males: Common warning signs

-
Image
fluciclovine f 18 :: Article Creator The U.S. Navy Might Be Done With The F/A-18 Super Hornet Fighter Will The U.S. Navy Receive Its Final F/A-18 Super Hornets? - Around the holidays, money can be tight, a fact that the United States Navy has also learned as its negotiations to buy the last batch of Super Hornets are reportedly stalled over the growing price tag. USNI News reported on Tuesday that the contract for the U.S. Navy to purchase the final twenty F/A-18 E/F Super Hornets from aerospace giant Boeing appears to be at a standstill. The Navy continues to work with Boeing on the contract for the 20 congressionally added Super Hornet aircraft. Ongoing contract negotiations cannot be discussed at this time," Capt. Michael Burks, the program manager for the F/A-18 and EA-18G office at Naval Air Systems Command, told USNI News in a statement. Previous estimates put the unit cost of the final batch of aircraft at $55.7 million, and la
Read more

20 Famous Men Who Have Had Prostate Cancer

-
Image
leukemia treatment options :: Article Creator Current And Breakthrough Treatments For Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is a slow-growing cancer of the immune system. Because it's slow-growing, many people with CLL won't need to start treatment for many years after their diagnosis. Once the cancer begins to grow, there are many available treatment options that can help people achieve remission. This means people can experience long periods of time when there's no sign of cancer in their bodies. The exact treatment option that you'll receive depends on a variety of factors. This includes: whether your CLL is symptomatic the stage of the CLL, based on results of blood tests and a physical exam your age your overall health While there's no cure for CLL yet, breakthroughs in the field are on the horizon. Doctors typically stage CLL using a system called the Rai system. Low
Read more