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Successful Whole-exome Sequencing From A Prostate Cancer Bone Metastasis Biopsy

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What To Know About Lung Adenocarcinoma

A lung adenocarcinoma is a type of non-small cell lung cancer (NSCLC) that begins in the glandular cells of the lungs. Depending on the stage, this can be a serious illness. However, treatment can improve a person's outcome.

According to the American Cancer Society (ACS), lung cancer is the second most common type of cancer in both males and females.

Among lung cancer types, lung adenocarcinoma is most frequently observed. Most cancers that begin in the breast, pancreas, and prostate also are adenocarcinomas.

Read on to learn more about lung adenocarcinoma, its symptoms, treatment, and outlook.

There are two predominant types of lung cancer:

The ACS reports that NSCLC is much more common, making up 80% to 85% of all lung cancers.

Lung adenocarcinoma is a type of NSCLC, with the two others being squamous cell lung carcinoma and large cell carcinoma. About 40% of all lung cancers are NSCLC, according to the National Cancer Institute (NCI).

It begins in the glandular cells, which create and release fluids such as mucus and line the walls of your alveoli, the tiny air sacs in your lungs. When they turn cancerous, they begin to grow abnormally. They're often found on the outer parts of the lungs.

Adenocarcinoma of the lung can be further divided into different subtypes based on factors like:

  • the size of the tumor
  • how the cancer cells look under a microscope
  • whether the cancer has started to invade surrounding tissues
  • Early on, a person with NSCLC may not experience symptoms. Once symptoms appear, they usually include a cough that does not go away. NSCLC can also cause chest pain when taking a deep breath, coughing, or laughing.

    Other symptoms include:

  • shortness of breath
  • fatigue
  • wheezing
  • coughing up blood
  • phlegm that's brownish or reddish in color
  • persistent cough
  • hoarseness
  • chest pain
  • unintentional weight loss
  • reduced appetite
  • The outlook for people with lung cancer is better when the cancer is found and treated early. If you develop any of the symptoms above, make an appointment with a doctor. They can perform tests to help find what's causing your symptoms.

    NSCLC tends to form in the cells along the outer part of the lungs. In the precancerous stage, cells undergo genetic changes that cause the abnormal cells to grow faster.

    Further genetic alterations may lead to changes that help the cancer cells grow and form a mass or tumor. Cells that make up a lung cancer tumor can break off and spread to other parts of the body.

    The growth of lung adenocarcinoma happens in the following stages:

  • Stage 0: The cancer has not spread beyond the inner lining of the lungs.
  • Stage 1: The cancer is still early stage and has not spread to the lymph system.
  • Stage 2: The cancer has spread to some lymph nodes near the lungs.
  • Stage 3: The cancer has spread to other lymph nodes or tissue.
  • Stage 4: The lung cancer has spread to other organs.
  • How serious is adenocarcinoma of the lung?

    Depending on the stage of diagnosis, lung adenocarcinoma can be a serious illness. The more the cancer has spread, the more ongoing treatment you will need.

    That said, a variety of factors can affect your outlook with adenocarcinoma of the lung. These include:

  • the stage of your cancer
  • the subtype of adenocarcinoma of the lung that you have
  • how well your lungs are functioning
  • whether certain genetic changes are present in the cancer cells
  • your age and overall health
  • Having a family history of lung cancer raises your chance of developing it yourself. Certain genetic mutations can also predispose you to it.

    Other risk factors include:

  • Smoking: People who smoke have a higher risk of developing lung cancer, according to the Centers for Disease Control and Prevention (CDC). Tobacco smoke contains thousands of different chemicals, and at least 70 of them are known to cause cancer. However, nonsmokers can also develop this cancer.
  • Pollution and chemicals: Breathing highly polluted air can also raise your chance of developing lung cancer. This especially includes the gas radon. Breathing in chemicals found in diesel exhaust, coal products, and other hazardous materials like asbestos, uranium, arsenic, cadmium, and chromium increases your risk.
  • Sex: Research indicates that females may be more at risk than males for this type of lung disease.
  • Age: Younger people with lung cancer are more likely to have non-small cell adenocarcinoma than other forms of lung cancer, according to research discussed in a 2022 study.
  • To diagnose lung adenocarcinoma of the lung, your doctor will first request your medical history. They'll ask about the symptoms you're having if you currently or have previously smoked and if you have a family history of lung cancer.

    They'll then perform a physical examination. At this time, they'll get your vital signs and will listen to your lungs as you breathe.

    The tests that may be ordered to help diagnose adenocarcinoma of the lung are:

  • Blood tests: This can be a complete blood count or a blood chemistry test.
  • Imaging tests: These may be a chest X-ray, a computed tomography (CT) scan, or a positron emission tomography (PET) scan.
  • Bronchoscopy: During a bronchoscopy, your doctor will use a thin, flexible tube with a camera on the end to look inside your airways for signs of cancer. Your doctor may also request that tissue samples be collected.
  • Sputum cytology: A doctor will view a mucus sample under a microscope to look for cancer cells. This test may not be as helpful for adenocarcinoma of the lung since this cancer is often on the outer edges of the lungs.
  • Thoracentesis: If fluid is present in the space between your chest wall and lungs, your doctor will use a needle to remove a fluid sample. It can be reviewed under a microscope to look for cancer cells.
  • Share on PinterestCT scan of lung adenocarcinoma. Credit: Yale Rosen from USA, CC BY-SA 2.0, via Wikimedia Commons

    A lung biopsy is the only way to definitively diagnose adenocarcinoma of the lung. If the tests above raise suspicions of lung cancer, your doctor will request that a biopsy be collected from the affected area and examined under a microscope to look for signs of cancer.

    This tissue can also be tested for proteins or genetic changes associated with adenocarcinoma of the lung. If present, they can affect outlook and may also be targets for treatments like targeted therapy and immunotherapy.

    An effective treatment for non-small cell adenocarcinoma depends on the cancer's stage. It may include:

  • Chemotherapy: This may be done before surgery to shrink a tumor (neoadjuvant therapy) or after surgery to help kill any remaining cancer cells (adjuvant therapy)
  • Radiation: This may be needed when surgery is not an option due to the extent of the cancer. It can also be used as a neoadjuvant or adjuvant therapy.
  • Targeted therapy: These drugs home in on specific markers associated with cancer cells.
  • Immunotherapy: These drugs help your immune system respond to cancer cells, usually in more advanced adenocarcinoma of the lung.
  • Surgery to remove all or only part of the lung is often required if the cancer has not spread. Other treatments are more likely to be needed if the cancer has spread.

    Is lung adenocarcinoma cancer curable?

    While it's not impossible to cure lung adenocarcinoma, this is often difficult because the condition is commonly diagnosed at an advanced stage.

    Overall, the 5-year survival rate for NSCLC depends on whether the cancer has spread:

    That said, research suggests that people with lung adenocarcinoma may have a slightly higher 5-year survival rate compared to those with other types of lung cancer (32.3% vs 25.4%).

    People with two subtypes of adenocarcinoma of the lung, adenocarcinoma in situ and minimally invasive adenocarcinoma have a better outcome, especially when the cancer is treated early with surgery. If surgery completely removes the cancer, the 5-year survival rate approaches 100%.

    That said, survival rates are calculated based on data from many people with NSCLC and do not account for individual factors or recent advances in diagnosis and treatment. Overall, it's best to discuss your individual outlook with your care team.

    A lung adenocarcinoma is a form of NSCLC originating in the glandular cells of the lungs. Depending on its stage, this can be potentially life threatening. There are treatment options available that may lead to better outcomes.

    Doctors and researchers also continue to develop newer, more effective treatments for adenocarcinoma of the lung. These can include new targeted therapy or immunotherapy drugs or new ways to use existing treatments.

    Before being used on a larger scale, these new treatments need to be tested in clinical trials. If you're interested in taking part in a clinical trial, talk with your care team. They can help you to find one that you would be a good candidate for.

    You can also consider looking at clinical trials supported by the NCI. The LUNGevity Foundation also provides a clinical trial matching service via the phone or an online search tool.

    Read this article in Spanish.


    Georgia WWII Hero's Grave Inspires Songwriter Ballad Decades After Soldier Killed In Combat

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    FIRST ON FOX: A World War II hero from backwoods Georgia inspires Americans today even from the grave. 

    The story of U.S. Army PFC Ervin O. Jones is worthy of a song.

    Craig Gleason, a Georgia songwriter, penned "The Ballad of Ervin O. Jones" in 2014, after he and his daughter came across the soldier's headstone in a churchyard cemetery in the city of Alpharetta. 

    AMERICAN WORLD WAR II HEROES, ADOPTED IN 'FACES OF MARGRATEN' PROJECT BY 'GRATEFUL' DUTCH PEOPLE

    "It's a powerful story, man. It's powerful," Gleason said Sunday in a telephone interview with Fox News Digital.

    Gleason, in turn, teaches the art of songwriting to struggling veterans who attend Warrior Week each month at Camp Southern Ground in Fayetteville, Georgia.

    U.S. Army PFC Ervin O. Jones of Alpharetta, Georgia, was just 20 years old when he was killed in the Battle of Okinawa in 1945. Seven decades later, his Georgia gravestone inspired musician Craig Gleason to write "The Ballad of Ervin O. Jones." (Jones Family/Craig Gleason)

    Grammy Award-winning musician Zac Brown founded the camp in 2011. Gleason is a former coordinator for the Nashville Songwriters Association. 

    Gleason looked at a church cemetery near his home in Alpharetta as an opportunity to learn about, and teach his daughter, then aged 12, about local history.

    "When you homeschool your children, you use real-life experiences, every place you go and everyone you meet, as a learning experience," said Gleason. 

    THESE 5 US MILITARY CEMETERIES IN SURPRISING NATIONS ARE LASTING REMINDERS OF AMERICA'S GLOBAL SACRIFICE

    It's the same skill used by songwriters to take everyday experiences and interpret them for others through the human gift of music. 

    "I told Audrey, you can learn a lot from these tombstones." 

    The Gleasons found out about a hometown hero buried in their midst. Along the way, they earned a lesson about the grief that grips a family decades after wartime loss. 

    U.S. Army PFC Ervin O. Jones of Alpharetta, Georgia, was just 20 years old when he was killed during the Battle of Okinawa in 1945. His gravestone inspired musician Craig Gleason to write "The Ballad of Ervin O. Jones." (Jones Family/Craig Gleason)

    PFC Jones was just 20 years old when he was killed on the island of Ieshima during the Battle of Okinawa on April 17, 1945, as Americans forces closed in on the home islands of Imperial Japan. 

    Gleason was haunted by the grave and was moved to write about the soldier. But he wanted to know the real story about the young man resting under the headstone near his home. 

    He soon learned that PFC Jones' younger brother, Curtis, was still alive and living nearby, in Canton, Georgia. 

    MEMORIAL DAY: IMPORTANT FACTS ABOUT THE SOLEMN AMERICAN HOLIDAY

    "Curtis was living in a little trailer out in the woods and I knocked on his door and introduced myself," said Gleason. "I said, 'I'm writing a song about your brother Ervin' and asked if we could talk."

    He added, "Curtis was like old-school backwoods Georgia. Real salt of the Earth. He invited me in and for the next three or four hours in his living room he pulled out artifacts, pictures and an old guitar that Ervin owned." 

    Turns out that Gleason and the forever-young dirt-poor Georgia farmboy shared the gift of music.

    Curtis Jones, now deceased, lived his adult life with the pain of his older brother's death during World War II. PFC Ervin O. Jones was killed on the Japanese island of Ieshima on April 17, 1945.  (Jones Family/Craig Gleason)

    "We laughed and cried, and by the end I felt like I had become part of that family within just a few hours."

    Among other things, Gleason learned that the former stranger, PFC Jones, died a hero. 

    "His courage and aggressiveness in this action was truly an inspiration to the officers and men in his company," his commanding officer, Capt. William B. Cooper, wrote in July 1945, in a letter addressed to the soldier's mother, Jennie. 

    (Here's the song below, embedded with permission from Craig Gleason, creator and copyright owner.)

    One of Gleason's most painful discoveries was that Jones' parents never fully coped with the overwhelming grief they suffered upon learning of their son's death.

    "Granny Jennie and Papa Harmon never mentioned Ervin, and we visited them every Sunday until they passed," PFC's nephew and his wife, John and Judy Jones, said via text message on Sunday.

    "American patriots and war heroes, much like songs, grow from the most humble circumstances."

    "The pain of the loss of their firstborn son Ervin never went away and they grieved until they died."

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    Gleason learned one other lesson — a powerful lesson he said he tries to pass on to aspiring musicians, veterans, everyday Americans and the people for whom he performs "The Ballad of Ervin O. Jones."

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    He learned that American patriots and war heroes, much like songs, grow from the most humble circumstances.

    Army PFC Ervin O. Jones was killed on April 17, 1945, during the Battle of Okinawa. His Georgia grave inspired musician Craig Gleason to write "The Ballad of Ervin O. Jones" seven decades later. (Jones Family/Craig Gleason and Will Lester/MediaNews Group/Inland Valley Daily Bulletin via Getty Images)

    He writes, and sings, in the last lines of the ballad: "From the lowlands to the highlands / Across every stick and stone / Came heroes who gave and lost their lives / Heroes like Ervin O. Jones."

    For more Lifestyle articles, visit www.Foxnews.Com/lifestyle.






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